Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1256668..1257170 Replicon chromosome
Accession NZ_CP043004
Organism Aggregatibacter actinomycetemcomitans strain HK_973

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag FXN59_RS06635 Protein ID WP_148325251.1
Coordinates 1256668..1256922 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID -
Locus tag FXN59_RS06640 Protein ID WP_148325252.1
Coordinates 1256919..1257170 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN59_RS06620 (FXN59_06620) 1252600..1254774 + 2175 WP_148327347.1 DNA helicase II -
FXN59_RS06625 (FXN59_06625) 1254907..1255569 - 663 WP_233444034.1 DNA ligase -
FXN59_RS12545 1255582..1255734 - 153 WP_233444035.1 hypothetical protein -
FXN59_RS06630 (FXN59_06630) 1255912..1256655 - 744 WP_148325250.1 YdcF family protein -
FXN59_RS06635 (FXN59_06635) 1256668..1256922 - 255 WP_148325251.1 Txe/YoeB family addiction module toxin Toxin
FXN59_RS06640 (FXN59_06640) 1256919..1257170 - 252 WP_148325252.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FXN59_RS06645 (FXN59_06645) 1257279..1258235 - 957 WP_148327348.1 polysaccharide pyruvyl transferase family protein -
FXN59_RS06650 (FXN59_06650) 1258232..1259755 - 1524 WP_151294513.1 polysaccharide biosynthesis protein -
FXN59_RS06655 (FXN59_06655) 1259951..1260718 + 768 WP_151294074.1 IS5-like element ISAac2 family transposase -
FXN59_RS06660 (FXN59_06660) 1260780..1261553 + 774 WP_187373635.1 glycosyltransferase family 25 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1259951..1260718 767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10216.77 Da        Isoelectric Point: 9.7542

>T136912 WP_148325251.1 NZ_CP043004:c1256922-1256668 [Aggregatibacter actinomycetemcomitans]
MILAWTKTAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>T136912 NZ_CP043004:c1256922-1256668 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGAAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACATTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9378.66 Da        Isoelectric Point: 5.0637

>AT136912 WP_148325252.1 NZ_CP043004:c1257170-1256919 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLAAIDQLNSGKIIERE
LQE

Download         Length: 252 bp

>AT136912 NZ_CP043004:c1257170-1256919 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCATTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGAGAGCGTTTATTAGCCGCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References