Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 868727..869380 Replicon chromosome
Accession NZ_CP043004
Organism Aggregatibacter actinomycetemcomitans strain HK_973

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FXN59_RS04625 Protein ID WP_005567475.1
Coordinates 869198..869380 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FXN59_RS04620 Protein ID WP_151294346.1
Coordinates 868727..869146 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN59_RS04565 (FXN59_04565) 863881..864195 - 315 WP_015971210.1 hypothetical protein -
FXN59_RS04575 (FXN59_04575) 864486..864737 + 252 Protein_869 transcriptional regulator -
FXN59_RS04580 (FXN59_04580) 864795..865817 + 1023 WP_187387016.1 N-acetyltransferase -
FXN59_RS04585 (FXN59_04585) 865792..866067 - 276 WP_148327382.1 hypothetical protein -
FXN59_RS04590 (FXN59_04590) 866406..866762 + 357 WP_148327383.1 DUF2513 domain-containing protein -
FXN59_RS04595 (FXN59_04595) 866915..867094 + 180 WP_019518459.1 hypothetical protein -
FXN59_RS04600 (FXN59_04600) 867094..867507 + 414 WP_019518460.1 hypothetical protein -
FXN59_RS04605 (FXN59_04605) 867601..867825 + 225 WP_005545968.1 hypothetical protein -
FXN59_RS04610 (FXN59_04610) 868044..868286 + 243 WP_262404602.1 hypothetical protein -
FXN59_RS12450 868283..868741 + 459 WP_262404603.1 helix-turn-helix domain-containing protein -
FXN59_RS04620 (FXN59_04620) 868727..869146 - 420 WP_151294346.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FXN59_RS04625 (FXN59_04625) 869198..869380 - 183 WP_005567475.1 type II toxin-antitoxin system HicA family toxin Toxin
FXN59_RS04630 (FXN59_04630) 869634..869852 + 219 WP_151294348.1 hypothetical protein -
FXN59_RS04635 (FXN59_04635) 869928..870695 - 768 WP_151294074.1 IS5-like element ISAac2 family transposase -
FXN59_RS04640 (FXN59_04640) 870716..871180 + 465 WP_151294350.1 hypothetical protein -
FXN59_RS12455 871294..871800 + 507 Protein_883 baseplate J/gp47 family protein -
FXN59_RS04650 (FXN59_04650) 872023..873435 - 1413 Protein_884 ribose ABC transporter ATP-binding protein RbsA -
FXN59_RS04655 (FXN59_04655) 873446..873865 - 420 WP_148324370.1 D-ribose pyranase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - yhxB/manB 862598..897642 35044
- flank IS/Tn - - 869928..870695 767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6938.10 Da        Isoelectric Point: 10.1091

>T136911 WP_005567475.1 NZ_CP043004:c869380-869198 [Aggregatibacter actinomycetemcomitans]
MKYSEFLRYLLEQGCKVEATKRGSHRKVTLNDCQTVFPYHGSKEIGTGLVHKIKKDLNLK

Download         Length: 183 bp

>T136911 NZ_CP043004:c869380-869198 [Aggregatibacter actinomycetemcomitans]
ATGAAATACAGTGAATTCTTGCGATACTTGCTTGAGCAAGGCTGCAAAGTCGAAGCAACCAAGCGCGGAAGTCATCGCAA
GGTAACGTTGAATGACTGCCAAACTGTCTTTCCCTACCATGGTAGTAAAGAAATCGGTACCGGCTTAGTTCACAAAATCA
AAAAAGACTTAAACTTAAAATAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15930.41 Da        Isoelectric Point: 4.7175

>AT136911 WP_151294346.1 NZ_CP043004:c869146-868727 [Aggregatibacter actinomycetemcomitans]
MLRYPVEITPDDNGTFLVTCPDIPEMVSVGEDIESALLEAEEGLETALEFYFDDKRPIPMPSQQKDGQYTVPLSLLRSLK
VFLLNEMLAQGVRKAEMARRLDVHMPQVDRLLDFRHPSKIDFVEKAFKKLGREINLSVH

Download         Length: 420 bp

>AT136911 NZ_CP043004:c869146-868727 [Aggregatibacter actinomycetemcomitans]
ATGTTACGCTACCCTGTTGAAATCACCCCGGATGATAACGGTACATTCCTTGTCACTTGCCCCGATATTCCCGAAATGGT
AAGTGTAGGTGAAGATATTGAAAGCGCACTACTTGAAGCGGAAGAAGGTTTAGAAACCGCCCTTGAATTTTATTTTGATG
ATAAACGCCCAATTCCAATGCCAAGCCAGCAAAAAGATGGGCAATATACGGTTCCGCTTTCCTTATTGCGTTCACTAAAA
GTCTTCTTACTCAATGAAATGCTCGCACAAGGTGTGCGAAAAGCTGAAATGGCGCGCCGTCTTGATGTTCACATGCCGCA
AGTCGATCGCTTATTAGATTTTCGCCACCCATCCAAAATTGATTTTGTTGAAAAAGCCTTTAAAAAATTAGGGCGCGAAA
TTAATTTATCGGTTCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References