Detailed information of TA system TA136908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 1753925..1754522
• Replicon: chromosome
• Accession: NZ_CP043003
• Organism: Aggregatibacter actinomycetemcomitans strain HK_907

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FXN58_RS09100
• Protein ID: WP_148325441.1
• Coordinates: 1753925..1754227 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: G4A710
• Locus tag: FXN58_RS09105
• Protein ID: WP_005556438.1
• Coordinates: 1754229..1754522 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN58_RS09085 (FXN58_09080)	1750557..1750901	-	345	Protein_1739	glucose-1-phosphate adenylyltransferase	-
FXN58_RS09090 (FXN58_09085)	1750993..1751760	+	768	WP_148323191.1	IS5-like element ISAac2 family transposase	-
FXN58_RS09095 (FXN58_09090)	1751827..1753772	-	1946	Protein_1741	ABC transporter ATP-binding protein	-
FXN58_RS09100 (FXN58_09095)	1753925..1754227	+	303	WP_148325441.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FXN58_RS09105 (FXN58_09100)	1754229..1754522	+	294	WP_005556438.1	putative addiction module antidote protein	Antitoxin
FXN58_RS09110 (FXN58_09105)	1754559..1755911	-	1353	WP_148325442.1	anti-phage deoxyguanosine triphosphatase	-
FXN58_RS09115 (FXN58_09110)	1755913..1756605	-	693	WP_148325443.1	CidB/LrgB family autolysis modulator	-
FXN58_RS09120 (FXN58_09115)	1756605..1757015	-	411	WP_148325444.1	CidA/LrgA family protein	-
FXN58_RS09125 (FXN58_09120)	1757194..1757961	+	768	WP_148325049.1	IS5-like element ISAac2 family transposase	-
FXN58_RS09135 (FXN58_09130)	1758479..1759480	+	1002	WP_148325445.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1750993..1751760	767

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-89)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11399.99 Da
• Isoelectric Point: 8.3464

>T136908 WP_148325441.1 NZ_CP043003:1753925-1754227 [Aggregatibacter actinomycetemcomitans]
MYIIEETEEFSNWLENLTDELAIVNIVARIGRAKLGNFGDHKSVGNGVYEMRITKGKGYRIYYARKGDITYLLILGGDKS
SQEKDIKNAKALWQQIKNGE

Nucleotide

• Length: 303 bp

>T136908 NZ_CP043003:1753925-1754227 [Aggregatibacter actinomycetemcomitans]
ATGTATATAATTGAGGAAACGGAGGAATTCTCCAACTGGTTAGAGAATCTAACCGACGAACTTGCGATTGTGAATATTGT
CGCTCGAATTGGACGGGCAAAACTCGGTAATTTCGGCGATCATAAATCGGTGGGTAATGGCGTATATGAAATGCGAATTA
CAAAAGGGAAAGGATACAGAATCTACTATGCAAGAAAGGGAGATATTACTTATTTATTAATTCTTGGCGGCGATAAATCA
AGCCAAGAAAAAGATATTAAGAATGCAAAAGCACTATGGCAACAAATTAAAAACGGAGAATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10694.39 Da
• Isoelectric Point: 6.3545

>AT136908 WP_005556438.1 NZ_CP043003:1754229-1754522 [Aggregatibacter actinomycetemcomitans]
MTVTTREFDAARYLKNEKMMAMYLETVLEEGTTAEFIQALNTVARAKGMSELAEKTGIGRESLYKTLSSEKPRFDTILKI
ISALGLSLSINAKDAVA

Nucleotide

• Length: 294 bp

>AT136908 NZ_CP056307:c4785400-4785134 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A142FXE9