Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1467349..1467941 Replicon chromosome
Accession NZ_CP043003
Organism Aggregatibacter actinomycetemcomitans strain HK_907

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FXN58_RS07715 Protein ID WP_005542431.1
Coordinates 1467349..1467648 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FXN58_RS07720 Protein ID WP_005542432.1
Coordinates 1467645..1467941 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN58_RS07690 (FXN58_07685) 1462626..1463840 - 1215 WP_148325270.1 molybdopterin molybdotransferase MoeA -
FXN58_RS07695 (FXN58_07690) 1463969..1464625 + 657 WP_148325271.1 GTP cyclohydrolase I FolE -
FXN58_RS07700 (FXN58_07695) 1464726..1466168 - 1443 WP_148325272.1 serine-type D-Ala-D-Ala carboxypeptidase -
FXN58_RS07705 (FXN58_07700) 1466327..1466803 + 477 WP_148325273.1 transcription elongation factor GreA -
FXN58_RS07710 (FXN58_07705) 1466879..1467181 - 303 WP_005545243.1 ribosome assembly RNA-binding protein YhbY -
FXN58_RS07715 (FXN58_07710) 1467349..1467648 + 300 WP_005542431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FXN58_RS07720 (FXN58_07715) 1467645..1467941 + 297 WP_005542432.1 putative addiction module antidote protein Antitoxin
FXN58_RS07725 (FXN58_07720) 1467974..1468588 - 615 WP_148325274.1 riboflavin synthase subunit alpha -
FXN58_RS07730 (FXN58_07725) 1468615..1470012 + 1398 WP_148325275.1 MATE family efflux transporter -
FXN58_RS07735 (FXN58_07730) 1470278..1472437 + 2160 WP_148325276.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11407.47 Da        Isoelectric Point: 10.4825

>T136907 WP_005542431.1 NZ_CP043003:1467349-1467648 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T136907 NZ_CP043003:1467349-1467648 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAAAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATGAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCTTGCTTTGTGGCGGAGATAAA
TCCACTCAAGAGAAAGATATTAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10852.32 Da        Isoelectric Point: 4.3776

>AT136907 WP_005542432.1 NZ_CP043003:1467645-1467941 [Aggregatibacter actinomycetemcomitans]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT136907 NZ_CP043003:1467645-1467941 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAAATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCAGCTTTATTTAAATGAAGT
GCTACAGGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATTGCACGAGCCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGCTTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References