Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1435983..1436485 Replicon chromosome
Accession NZ_CP043003
Organism Aggregatibacter actinomycetemcomitans strain HK_907

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag FXN58_RS07545 Protein ID WP_148325251.1
Coordinates 1435983..1436237 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID -
Locus tag FXN58_RS07550 Protein ID WP_148325252.1
Coordinates 1436234..1436485 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN58_RS07530 (FXN58_07525) 1431916..1434090 + 2175 WP_148325248.1 DNA helicase II -
FXN58_RS07535 (FXN58_07530) 1434223..1435050 - 828 WP_148325249.1 DNA ligase -
FXN58_RS07540 (FXN58_07535) 1435227..1435970 - 744 WP_148325250.1 YdcF family protein -
FXN58_RS07545 (FXN58_07540) 1435983..1436237 - 255 WP_148325251.1 Txe/YoeB family addiction module toxin Toxin
FXN58_RS07550 (FXN58_07545) 1436234..1436485 - 252 WP_148325252.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FXN58_RS07555 (FXN58_07550) 1436594..1437550 - 957 WP_148325253.1 polysaccharide pyruvyl transferase family protein -
FXN58_RS07560 (FXN58_07555) 1437547..1439070 - 1524 WP_148325254.1 polysaccharide biosynthesis protein -
FXN58_RS07565 (FXN58_07560) 1439266..1440033 + 768 WP_148325255.1 IS5 family transposase -
FXN58_RS07570 (FXN58_07565) 1440095..1440868 + 774 WP_187373635.1 glycosyltransferase family 25 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1439266..1440033 767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10216.77 Da        Isoelectric Point: 9.7542

>T136905 WP_148325251.1 NZ_CP043003:c1436237-1435983 [Aggregatibacter actinomycetemcomitans]
MILAWTKTAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>T136905 NZ_CP056307:c2715426-2714104 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGATAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGCGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9378.66 Da        Isoelectric Point: 5.0637

>AT136905 WP_148325252.1 NZ_CP043003:c1436485-1436234 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLAAIDQLNSGKIIERE
LQE

Download         Length: 252 bp

>AT136905 NZ_CP043003:c1436485-1436234 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCATTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGAGAGCGTTTATTAGCCGCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References