Detailed information of TA system TA136900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 2131429..2132336
• Replicon: chromosome
• Accession: NZ_CP043002
• Organism: Bifidobacterium longum strain BAMA-B05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FVF69_RS09445
• Protein ID: WP_131203652.1
• Coordinates: 2131791..2132336 (+)
• Length: 182 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q8G4I4
• Locus tag: FVF69_RS09440
• Protein ID: WP_011068030.1
• Coordinates: 2131429..2131791 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVF69_RS09435	2128584..2131283	+	2700	WP_007054466.1	aconitate hydratase AcnA	-
FVF69_RS09440	2131429..2131791	+	363	WP_011068030.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FVF69_RS09445	2131791..2132336	+	546	WP_131203652.1	PIN domain-containing protein	Toxin
FVF69_RS09450	2132356..2134461	-	2106	WP_131203651.1	DUF262 domain-containing protein	-
FVF69_RS09455	2134550..2135191	-	642	WP_165506474.1	GNAT family N-acetyltransferase	-
FVF69_RS09460	2135231..2135956	-	726	WP_007056206.1	response regulator transcription factor	-
FVF69_RS09465	2135991..2137223	-	1233	WP_007056207.1	sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-141)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-53)

Sequences

Toxin

Protein

• Length: 182 a.a.
• Molecular weight: 20109.79 Da
• Isoelectric Point: 4.6773

>T136900 WP_131203652.1 NZ_CP043002:2131791-2132336 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRSEFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDRAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALRGGTGINERLASLTEGSHQ

Nucleotide

• Length: 546 bp

>T136900 NZ_CP056307:387783-388130 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 14004.05 Da
• Isoelectric Point: 5.0733

>AT136900 WP_011068030.1 NZ_CP043002:2131429-2131791 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Nucleotide

• Length: 363 bp

>AT136900 NZ_CP043002:2131429-2131791 [Bifidobacterium longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTACACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATACGTATTACAACATGAAGAGGGCCGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S2W1N3