Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1013831..1014389 Replicon chromosome
Accession NZ_CP043001
Organism Histophilus somni strain UOC-KLM-ATR-04

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FWK45_RS05015 Protein ID WP_147797420.1
Coordinates 1013831..1014103 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FWK45_RS05020 Protein ID WP_132994429.1
Coordinates 1014096..1014389 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FWK45_RS04980 1008974..1009258 + 285 WP_075321052.1 integration host factor subunit beta -
FWK45_RS04985 1009378..1009662 + 285 WP_012340596.1 DUF1049 domain-containing protein -
FWK45_RS04990 1009672..1010868 + 1197 WP_075293930.1 lipopolysaccharide assembly protein LapB -
FWK45_RS04995 1010892..1011398 - 507 WP_075293929.1 GNAT family N-acetyltransferase -
FWK45_RS05000 1011388..1011687 - 300 WP_012340592.1 DUF1778 domain-containing protein -
FWK45_RS05005 1011886..1012167 - 282 WP_132994427.1 virulence factor -
FWK45_RS05010 1012605..1013746 + 1142 Protein_970 porin -
FWK45_RS05015 1013831..1014103 - 273 WP_147797420.1 type II toxin-antitoxin system YafQ family toxin Toxin
FWK45_RS05020 1014096..1014389 - 294 WP_132994429.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FWK45_RS05025 1014848..1015228 - 381 WP_075293926.1 SufE family protein -
FWK45_RS05030 1015225..1016424 - 1200 WP_132994432.1 cysteine desulfurase -
FWK45_RS05035 1016414..1016917 - 504 WP_041604213.1 thermonuclease family protein -
FWK45_RS05040 1017043..1017459 + 417 WP_075293924.1 CidA/LrgA family protein -
FWK45_RS05045 1017456..1018145 + 690 WP_075293923.1 CidB/LrgB family autolysis modulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(19-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-59)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10302.98 Da        Isoelectric Point: 6.9468

>T136898 WP_147797420.1 NZ_CP043001:c1014103-1013831 [Histophilus somni]
MAKRNCGVTLPCKRDLRKHYLALVGEAWAEISNCLLNDLPIPEKYQDHPLKGDKSGFRDCHVKPDLVLIYKIVDVIVELH
YLDSHSEIFG

Download         Length: 273 bp

>T136898 NZ_CP043001:c1014103-1013831 [Histophilus somni]
ATGGCTAAACGTAATTGTGGCGTTACATTACCTTGTAAACGTGATTTGAGAAAACATTACTTGGCTTTAGTCGGCGAAGC
ATGGGCAGAGATTTCAAACTGTCTTTTGAATGACTTGCCAATTCCTGAAAAGTATCAAGATCACCCGCTTAAAGGCGATA
AATCAGGCTTTCGAGACTGCCATGTCAAACCGGATTTAGTGTTGATATACAAAATCGTTGACGTTATTGTGGAGTTACAT
TACCTTGATAGCCATAGCGAAATTTTTGGCTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11329.67 Da        Isoelectric Point: 5.1053

>AT136898 WP_132994429.1 NZ_CP043001:c1014389-1014096 [Histophilus somni]
MDYTNFNMRLDNDLRRRAYPILEQYGLTPSQAVRMFFNQIAQTGKIPLSFDWAENQTLTPKAAARLRQTEQEFANGEFER
FNSLDELNQAIKEISHG

Download         Length: 294 bp

>AT136898 NZ_CP056302:49967-50386 [Klebsiella pneumoniae]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References