Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 461421..462153 Replicon chromosome
Accession NZ_CP043001
Organism Histophilus somni strain UOC-KLM-ATR-04

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag FWK45_RS02375 Protein ID WP_011609926.1
Coordinates 461686..462153 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag FWK45_RS02370 Protein ID WP_011609927.1
Coordinates 461421..461684 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FWK45_RS02345 456526..456888 + 363 WP_135026582.1 hypothetical protein -
FWK45_RS02350 456965..459238 + 2274 WP_132995746.1 hypothetical protein -
FWK45_RS10280 459903..460592 + 690 WP_187383066.1 hypothetical protein -
FWK45_RS02360 460713..460971 + 259 Protein_455 DUF1778 domain-containing protein -
FWK45_RS02365 461047..461283 + 237 WP_011609928.1 hypothetical protein -
FWK45_RS02370 461421..461684 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
FWK45_RS02375 461686..462153 + 468 WP_011609926.1 GNAT family N-acetyltransferase Toxin
FWK45_RS02385 462832..463134 - 303 WP_147604091.1 DUF2442 domain-containing protein -
FWK45_RS02390 463103..463357 - 255 WP_075294104.1 DUF4160 domain-containing protein -
FWK45_RS02395 463492..463752 - 261 Protein_461 hemophilus-specific protein -
FWK45_RS02400 463829..464245 - 417 WP_075319814.1 IS200/IS605 family transposase -
FWK45_RS02405 464292..465428 + 1137 WP_075319813.1 transposase -
FWK45_RS02410 465684..466628 + 945 WP_147797376.1 hypothetical protein -
FWK45_RS02415 466634..467080 - 447 WP_011609888.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 463829..464245 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17307.31 Da        Isoelectric Point: 10.5068

>T136897 WP_011609926.1 NZ_CP043001:461686-462153 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALKNRQNRASRTFVICNENVVVGFYALAAGSVTQRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Download         Length: 468 bp

>T136897 NZ_CP043001:461686-462153 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAAAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCAGCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCGCCAATTGATGATATGTTATTGATGTTGAAGTTGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT136897 WP_011609927.1 NZ_CP043001:461421-461684 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT136897 NZ_CP056301:c5219954-5219712 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References