Detailed information of TA system TA136894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 8469993..8470687
• Replicon: chromosome
• Accession: NZ_CP042997
• Organism: Aquisphaera giovannonii strain OJF2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: OJF2_RS31370
• Protein ID: WP_148597337.1
• Coordinates: 8470244..8470687 (+)
• Length: 148 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: OJF2_RS31365
• Protein ID: WP_148597336.1
• Coordinates: 8469993..8470247 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OJF2_RS31350	8466124..8467545	+	1422	WP_148597333.1	ethanolamine ammonia-lyase subunit EutB	-
OJF2_RS31355	8467542..8469092	+	1551	WP_148597334.1	amino acid permease	-
OJF2_RS31360	8469079..8469939	+	861	WP_148597335.1	ethanolamine ammonia-lyase subunit EutC	-
OJF2_RS31365	8469993..8470247	+	255	WP_148597336.1	plasmid stabilization protein	Antitoxin
OJF2_RS31370	8470244..8470687	+	444	WP_148597337.1	type II toxin-antitoxin system VapC family toxin	Toxin
OJF2_RS31375	8471124..8472638	+	1515	WP_148597338.1	serine protease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 148 a.a.
• Molecular weight: 15685.11 Da
• Isoelectric Point: 7.0153

>T136894 WP_148597337.1 NZ_CP042997:8470244-8470687 [Aquisphaera giovannonii]
MIVLDTNVVSEAMKPKPAAVVVDWLDEQAAETLYLSSVTIAELLFGIGSLPEGRRKQKLMTAVDGLLHLFDGRILQFDTD
AARRYADLAVAARAAGKGFPTPDGYIAAIAVARGFLVATRDAIAFEAAGVAVINPWETKKGRPSRGT

Nucleotide

• Length: 444 bp

>T136894 NZ_CP056301:c4596776-4596243 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATATGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9035.26 Da
• Isoelectric Point: 10.6531

>AT136894 WP_148597336.1 NZ_CP042997:8469993-8470247 [Aquisphaera giovannonii]
MPAVTIRNLSEEAHRALKVRAAHHGRSTEAEMRAILEAAVRPADRVRIGSALSSLGRRAGLNGADVEALERARDGKPADP
MNIE

Nucleotide

• Length: 255 bp

>AT136894 NZ_CP056301:c4597053-4596787 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACTAGGTAA