Detailed information of TA system TA136888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1700337..1700818
• Replicon: chromosome
• Accession: NZ_CP042993
• Organism: Histophilus somni strain UOC-KLM-ATR-014

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FWK62_RS08020
• Protein ID: WP_165942816.1
• Coordinates: 1700558..1700818 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FWK62_RS08015
• Protein ID: WP_011608602.1
• Coordinates: 1700337..1700558 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK62_RS08005	1697977..1699900	-	1924	Protein_1545	transferrin-binding protein-like solute binding protein	-
FWK62_RS08010	1700176..1700274	-	99	Protein_1546	IS200/IS605 family transposase	-
FWK62_RS08015	1700337..1700558	+	222	WP_011608602.1	hypothetical protein	Antitoxin
FWK62_RS08020	1700558..1700818	+	261	WP_165942816.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FWK62_RS08030	1700997..1702454	-	1458	WP_147590400.1	DUF560 domain-containing protein	-
FWK62_RS08035	1702939..1703358	-	420	WP_075321652.1	pseudouridine synthase	-
FWK62_RS08040	1703424..1704764	-	1341	WP_075321653.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10128.82 Da
• Isoelectric Point: 10.1365

>T136888 WP_165942816.1 NZ_CP042993:1700558-1700818 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTRNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T136888 NZ_CP042993:1700558-1700818 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAATTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTAGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.60 Da
• Isoelectric Point: 4.4142

>AT136888 WP_011608602.1 NZ_CP042993:1700337-1700558 [Histophilus somni]
MAISVRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEDYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT136888 NZ_CP042993:1700337-1700558 [Histophilus somni]
ATGGCTATTTCAGTAAGACTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGACT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA