Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 1651613..1652250 Replicon chromosome
Accession NZ_CP042992
Organism Histophilus somni strain UOC-KLM-ATR-013

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FWK61_RS07450 Protein ID WP_011609928.1
Coordinates 1652014..1652250 (-) Length 79 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag FWK61_RS07445 Protein ID WP_011609927.1
Coordinates 1651613..1651876 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FWK61_RS07410 1647873..1649009 - 1137 WP_075319813.1 transposase -
FWK61_RS07415 1649056..1649472 + 417 WP_075319814.1 IS200/IS605 family transposase -
FWK61_RS07420 1649519..1649808 + 290 Protein_1425 hemophilus-specific protein -
FWK61_RS07425 1649940..1650194 + 255 WP_075294104.1 DUF4160 domain-containing protein -
FWK61_RS07430 1650163..1650465 + 303 WP_147604091.1 DUF2442 domain-containing protein -
FWK61_RS07440 1651144..1651611 - 468 WP_011609926.1 GNAT family N-acetyltransferase -
FWK61_RS07445 1651613..1651876 - 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
FWK61_RS07450 1652014..1652250 - 237 WP_011609928.1 hypothetical protein Toxin
FWK61_RS07455 1652326..1652581 - 256 Protein_1431 DUF1778 domain-containing protein -
FWK61_RS09885 1652702..1653391 - 690 WP_187378142.1 hypothetical protein -
FWK61_RS07465 1654056..1656329 - 2274 WP_132995746.1 hypothetical protein -
FWK61_RS07470 1656406..1656768 - 363 WP_135026582.1 hypothetical protein -
FWK61_RS07475 1656770..1657189 - 420 WP_178384271.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1649056..1649472 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 8873.59 Da        Isoelectric Point: 10.4575

>T136884 WP_011609928.1 NZ_CP042992:c1652250-1652014 [Histophilus somni]
MNLYLQKQVSQDIKRRIAPCFTVIDENKRILGYYTLASTSIPLVSLPENLKKKLPRYPSVPAVLLGRLAVDKQVSIFI

Download         Length: 237 bp

>T136884 NZ_CP042992:c1652250-1652014 [Histophilus somni]
TTGAATCTCTATTTACAAAAACAGGTTTCACAAGATATCAAAAGGCGTATTGCTCCTTGCTTTACTGTCATTGATGAAAA
TAAACGTATTTTAGGCTACTATACTTTAGCCTCAACAAGCATTCCTCTTGTCTCTCTCCCTGAGAACCTTAAGAAAAAAT
TACCCCGTTATCCTAGTGTTCCGGCGGTTTTACTTGGACGCTTAGCCGTTGACAAGCAAGTCTCAATATTCATTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT136884 WP_011609927.1 NZ_CP042992:c1651876-1651613 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT136884 NZ_CP042992:c1651876-1651613 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References