Detailed information of TA system TA136883

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 1651144..1651876
• Replicon: chromosome
• Accession: NZ_CP042992
• Organism: Histophilus somni strain UOC-KLM-ATR-013

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: FWK61_RS07440
• Protein ID: WP_011609926.1
• Coordinates: 1651144..1651611 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: FWK61_RS07445
• Protein ID: WP_011609927.1
• Coordinates: 1651613..1651876 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK61_RS07400	1646219..1646665	+	447	WP_011609888.1	hypothetical protein	-
FWK61_RS07405	1646592..1647617	-	1026	WP_148374756.1	hypothetical protein	-
FWK61_RS07410	1647873..1649009	-	1137	WP_075319813.1	transposase	-
FWK61_RS07415	1649056..1649472	+	417	WP_075319814.1	IS200/IS605 family transposase	-
FWK61_RS07420	1649519..1649808	+	290	Protein_1425	hemophilus-specific protein	-
FWK61_RS07425	1649940..1650194	+	255	WP_075294104.1	DUF4160 domain-containing protein	-
FWK61_RS07430	1650163..1650465	+	303	WP_147604091.1	DUF2442 domain-containing protein	-
FWK61_RS07440	1651144..1651611	-	468	WP_011609926.1	GNAT family N-acetyltransferase	Toxin
FWK61_RS07445	1651613..1651876	-	264	WP_011609927.1	DUF1778 domain-containing protein	Antitoxin
FWK61_RS07450	1652014..1652250	-	237	WP_011609928.1	hypothetical protein	-
FWK61_RS07455	1652326..1652581	-	256	Protein_1431	DUF1778 domain-containing protein	-
FWK61_RS09885	1652702..1653391	-	690	WP_187378142.1	hypothetical protein	-
FWK61_RS07465	1654056..1656329	-	2274	WP_132995746.1	hypothetical protein	-
FWK61_RS07470	1656406..1656768	-	363	WP_135026582.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1649056..1649472	416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-86)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17307.31 Da
• Isoelectric Point: 10.5068

>T136883 WP_011609926.1 NZ_CP042992:c1651611-1651144 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALKNRQNRASRTFVICNENVVVGFYALAAGSVTQRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Nucleotide

• Length: 468 bp

>T136883 NZ_CP042992:c1651611-1651144 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAAAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCAGCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCGCCAATTGATGATATGTTATTGATGTTGAAGTTGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9906.35 Da
• Isoelectric Point: 5.6388

>AT136883 WP_011609927.1 NZ_CP042992:c1651876-1651613 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Nucleotide

• Length: 264 bp

>AT136883 NZ_CP042992:c1651876-1651613 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA