Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1168326..1168884 Replicon chromosome
Accession NZ_CP042992
Organism Histophilus somni strain UOC-KLM-ATR-013

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FWK61_RS05200 Protein ID WP_148374724.1
Coordinates 1168612..1168884 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FWK61_RS05195 Protein ID WP_132994429.1
Coordinates 1168326..1168619 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FWK61_RS05170 1164567..1165256 - 690 WP_075293923.1 CidB/LrgB family autolysis modulator -
FWK61_RS05175 1165253..1165669 - 417 WP_075293924.1 CidA/LrgA family protein -
FWK61_RS05180 1165795..1166298 + 504 WP_041604213.1 thermonuclease family protein -
FWK61_RS05185 1166288..1167487 + 1200 WP_132994432.1 cysteine desulfurase -
FWK61_RS05190 1167484..1167864 + 381 WP_075293926.1 SufE family protein -
FWK61_RS05195 1168326..1168619 + 294 WP_132994429.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FWK61_RS05200 1168612..1168884 + 273 WP_148374724.1 type II toxin-antitoxin system YafQ family toxin Toxin
FWK61_RS05205 1168969..1169532 - 564 WP_148374725.1 porin -
FWK61_RS05210 1169547..1170110 - 564 WP_148374726.1 porin -
FWK61_RS05215 1170552..1170833 + 282 WP_132994427.1 virulence factor -
FWK61_RS05220 1171032..1171331 + 300 WP_012340592.1 DUF1778 domain-containing protein -
FWK61_RS05225 1171321..1171827 + 507 WP_075293929.1 GNAT family N-acetyltransferase -
FWK61_RS05230 1171851..1173047 - 1197 WP_075293930.1 lipopolysaccharide assembly protein LapB -
FWK61_RS05235 1173057..1173341 - 285 WP_012340596.1 DUF1049 domain-containing protein -
FWK61_RS05240 1173461..1173745 - 285 WP_075321052.1 integration host factor subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-59)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10455.09 Da        Isoelectric Point: 6.9569

>T136882 WP_148374724.1 NZ_CP042992:1168612-1168884 [Histophilus somni]
MAKRNCEMAKSFKRDLRKHYLALVGEAWAEISNCLLNDLPIPEKYQDHPLKGDKSGFRDCHVKPDLVLIYKIVNEIVELH
YLDSHSEIFG

Download         Length: 273 bp

>T136882 NZ_CP056297:3902374-3902592 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11329.67 Da        Isoelectric Point: 5.1053

>AT136882 WP_132994429.1 NZ_CP042992:1168326-1168619 [Histophilus somni]
MDYTNFNMRLDNDLRRRAYPILEQYGLTPSQAVRMFFNQIAQTGKIPLSFDWAENQTLTPKAAARLRQTEQEFANGEFER
FNSLDELNQAIKEISHG

Download         Length: 294 bp

>AT136882 NZ_CP042992:1168326-1168619 [Histophilus somni]
ATGGATTATACAAATTTTAATATGCGACTTGATAACGACTTGCGTAGACGAGCTTATCCTATTTTGGAGCAGTATGGATT
GACACCAAGTCAAGCGGTAAGAATGTTTTTTAATCAGATTGCACAAACCGGTAAAATACCCTTGTCGTTTGATTGGGCGG
AAAATCAAACGTTAACCCCAAAAGCAGCAGCACGATTACGCCAAACTGAGCAGGAATTCGCCAATGGCGAATTTGAACGC
TTTAATAGCCTAGATGAACTCAATCAAGCGATAAAGGAGATTTCGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References