Detailed information of TA system TA136880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 1651167..1651899
• Replicon: chromosome
• Accession: NZ_CP042991
• Organism: Histophilus somni strain UOC-KLM-ATR-012

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: FWK58_RS07345
• Protein ID: WP_075294106.1
• Coordinates: 1651167..1651634 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: FWK58_RS07350
• Protein ID: WP_011609927.1
• Coordinates: 1651636..1651899 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK58_RS07305	1646245..1646691	+	447	WP_075293401.1	hypothetical protein	-
FWK58_RS07310	1646710..1647639	-	930	WP_075293400.1	hypothetical protein	-
FWK58_RS07315	1647895..1649031	-	1137	WP_075319813.1	transposase	-
FWK58_RS07320	1649078..1649494	+	417	WP_075319814.1	IS200/IS605 family transposase	-
FWK58_RS07325	1649571..1649831	+	261	Protein_1405	hemophilus-specific protein	-
FWK58_RS07330	1649963..1650217	+	255	WP_075294104.1	DUF4160 domain-containing protein	-
FWK58_RS07335	1650186..1650488	+	303	WP_075294105.1	DUF2442 domain-containing protein	-
FWK58_RS07345	1651167..1651634	-	468	WP_075294106.1	GNAT family N-acetyltransferase	Toxin
FWK58_RS07350	1651636..1651899	-	264	WP_011609927.1	DUF1778 domain-containing protein	Antitoxin
FWK58_RS07355	1652037..1652348	-	312	WP_075294107.1	hypothetical protein	-
FWK58_RS07360	1652348..1652602	-	255	WP_075294108.1	DUF1778 domain-containing protein	-
FWK58_RS09745	1652756..1653412	-	657	WP_157665518.1	hypothetical protein	-
FWK58_RS07370	1654078..1656366	-	2289	WP_075321885.1	hypothetical protein	-
FWK58_RS07375	1656429..1656791	-	363	WP_135026582.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1649078..1649494	416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-86)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17344.33 Da
• Isoelectric Point: 10.5585

>T136880 WP_075294106.1 NZ_CP042991:c1651634-1651167 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Nucleotide

• Length: 468 bp

>T136880 NZ_CP042991:c1651634-1651167 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAGAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCATCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCACCAATTGATGATATGTTATTGATGTTGAAGTTATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9906.35 Da
• Isoelectric Point: 5.6388

>AT136880 WP_011609927.1 NZ_CP042991:c1651899-1651636 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Nucleotide

• Length: 264 bp

>AT136880 NZ_CP042991:c1651899-1651636 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA