Detailed information of TA system TA136876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1355907..1356506
• Replicon: chromosome
• Accession: NZ_CP042990
• Organism: Histophilus somni strain UOC-KLM-ATR-011

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UV74
• Locus tag: FWK55_RS05920
• Protein ID: WP_012340732.1
• Coordinates: 1355907..1356212 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0UV75
• Locus tag: FWK55_RS05925
• Protein ID: WP_012340733.1
• Coordinates: 1356216..1356506 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK55_RS05900	1351257..1352117	+	861	WP_075294502.1	RNase adapter RapZ	-
FWK55_RS05905	1352153..1354204	-	2052	WP_075294501.1	methionine--tRNA ligase	-
FWK55_RS05910	1354345..1355466	+	1122	WP_012340731.1	iron-sulfur cluster carrier protein ApbC	-
FWK55_RS05915	1355450..1355686	-	237	WP_080514392.1	recombinase family protein	-
FWK55_RS05920	1355907..1356212	-	306	WP_012340732.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FWK55_RS05925	1356216..1356506	-	291	WP_012340733.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FWK55_RS05930	1356678..1357241	-	564	WP_178384292.1	molecular chaperone	-
FWK55_RS05935	1357238..1357858	-	621	WP_011608731.1	NAD(P)H-dependent oxidoreductase	-
FWK55_RS05940	1357868..1358311	-	444	WP_012340735.1	NfeD family protein	-
FWK55_RS05945	1358358..1359278	-	921	WP_011608729.1	SPFH/Band 7/PHB domain protein	-
FWK55_RS05950	1359561..1360013	+	453	WP_011608728.1	type II 3-dehydroquinate dehydratase	-
FWK55_RS05955	1360202..1360663	+	462	WP_012340736.1	acetyl-CoA carboxylase biotin carboxyl carrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-97)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11745.47 Da
• Isoelectric Point: 8.9207

>T136876 WP_012340732.1 NZ_CP042990:c1356212-1355907 [Histophilus somni]
MSGKQLKVSYSKQFARDLTDLAKRYPNVLVGTKYITAMHCLLNRLPLPESYQDHTLVGEWKGYRDCHIQGDLVLIYQYVI
HDEFDALKFSRLNTYSQTASK

Nucleotide

• Length: 306 bp

>T136876 NZ_CP056297:342437-342805 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTTATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10804.13 Da
• Isoelectric Point: 4.2845

>AT136876 WP_012340733.1 NZ_CP042990:c1356506-1356216 [Histophilus somni]
MALTNASISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAMDELDSGNAESFFIEA
GENYSVEEFTKRILNG

Nucleotide

• Length: 291 bp

>AT136876 NZ_CP056297:342219-342440 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: B0UV74

Antitoxin

• AlphaFold DB: B0UV75