Detailed information of TA system TA136874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 481851..482332
• Replicon: chromosome
• Accession: NZ_CP042990
• Organism: Histophilus somni strain UOC-KLM-ATR-011

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FWK55_RS02240
• Protein ID: WP_136122252.1
• Coordinates: 481851..482111 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FWK55_RS02245
• Protein ID: WP_075294306.1
• Coordinates: 482111..482332 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK55_RS02215	477908..479248	+	1341	WP_075294311.1	PTS sugar transporter subunit IIC	-
FWK55_RS02220	479314..479733	+	420	WP_075294310.1	pseudouridine synthase	-
FWK55_RS02225	479912..480103	+	192	WP_075294309.1	hypothetical protein	-
FWK55_RS02230	480219..481673	+	1455	WP_136122251.1	DUF560 domain-containing protein	-
FWK55_RS02235	481737..481847	+	111	Protein_430	CAAX protease	-
FWK55_RS02240	481851..482111	-	261	WP_136122252.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FWK55_RS02245	482111..482332	-	222	WP_075294306.1	CopG family transcriptional regulator	Antitoxin
FWK55_RS02255	482768..484690	+	1923	WP_136122253.1	transferrin-binding protein-like solute binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10028.74 Da
• Isoelectric Point: 10.2656

>T136874 WP_136122252.1 NZ_CP042990:c482111-481851 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLKNCENPRIKGKGLTGNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T136874 NZ_CP042990:c482111-481851 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAACTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAAAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8543.65 Da
• Isoelectric Point: 4.4284

>AT136874 WP_075294306.1 NZ_CP042990:c482332-482111 [Histophilus somni]
MAISIRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEEYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT136874 NZ_CP042990:c482332-482111 [Histophilus somni]
ATGGCTATTTCAATAAGATTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGAAT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA