Detailed information of TA system TA136872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1355898..1356497
• Replicon: chromosome
• Accession: NZ_CP042989
• Organism: Histophilus somni strain UOC-KLM-ATR-010

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UV74
• Locus tag: FWK50_RS05915
• Protein ID: WP_012340732.1
• Coordinates: 1355898..1356203 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FWK50_RS05920
• Protein ID: WP_075294500.1
• Coordinates: 1356207..1356497 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK50_RS05895	1351248..1352108	+	861	WP_075294502.1	RNase adapter RapZ	-
FWK50_RS05900	1352144..1354195	-	2052	WP_075294501.1	methionine--tRNA ligase	-
FWK50_RS05905	1354336..1355457	+	1122	WP_012340731.1	iron-sulfur cluster carrier protein ApbC	-
FWK50_RS05910	1355441..1355677	-	237	WP_080514392.1	recombinase family protein	-
FWK50_RS05915	1355898..1356203	-	306	WP_012340732.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FWK50_RS05920	1356207..1356497	-	291	WP_075294500.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FWK50_RS05925	1356669..1357232	-	564	WP_178384292.1	molecular chaperone	-
FWK50_RS05930	1357229..1357849	-	621	WP_011608731.1	NAD(P)H-dependent oxidoreductase	-
FWK50_RS05935	1357859..1358302	-	444	WP_012340735.1	NfeD family protein	-
FWK50_RS05940	1358349..1359269	-	921	WP_011608729.1	SPFH/Band 7/PHB domain protein	-
FWK50_RS05945	1359552..1360004	+	453	WP_011608728.1	type II 3-dehydroquinate dehydratase	-
FWK50_RS05950	1360193..1360654	+	462	WP_012340736.1	acetyl-CoA carboxylase biotin carboxyl carrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-97)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11745.47 Da
• Isoelectric Point: 8.9207

>T136872 WP_012340732.1 NZ_CP042989:c1356203-1355898 [Histophilus somni]
MSGKQLKVSYSKQFARDLTDLAKRYPNVLVGTKYITAMHCLLNRLPLPESYQDHTLVGEWKGYRDCHIQGDLVLIYQYVI
HDEFDALKFSRLNTYSQTASK

Nucleotide

• Length: 306 bp

>T136872 NZ_CP042989:c1356203-1355898 [Histophilus somni]
ATGTCTGGTAAACAATTAAAGGTCAGTTACTCTAAACAATTTGCTAGAGATTTGACTGATTTGGCAAAACGTTACCCAAA
TGTGCTAGTAGGAACGAAATATATTACAGCAATGCACTGCTTGTTAAACCGCTTGCCATTGCCTGAAAGCTATCAAGATC
ACACATTAGTTGGAGAATGGAAAGGTTATCGAGATTGCCATATTCAAGGGGATTTGGTGCTGATTTACCAATACGTTATA
CACGATGAATTTGATGCGTTGAAATTTTCTCGTTTAAATACCTACTCGCAAACAGCTTCAAAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10832.18 Da
• Isoelectric Point: 4.2845

>AT136872 WP_075294500.1 NZ_CP042989:c1356497-1356207 [Histophilus somni]
MALTNASISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLVQIAKTRSIPVDLNYLRPNKETLAAMDELDSGNAESFFIEA
GENYSVEEFTKRILNG

Nucleotide

• Length: 291 bp

>AT136872 NZ_CP042989:c1356497-1356207 [Histophilus somni]
ATGGCACTTACAAATGCGTCTATCAGCTTTAGAACAGTTGAGCAAACTAAATCCGAAGCCTATCAGGTCATTGAACAATA
TGGTCTTACACCATCACAAGTATTTAATATGTTTTTGGTTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCTTAGCAGCTATGGACGAATTAGATAGCGGTAATGCAGAGAGCTTTTTTATTGAAGCT
GGAGAAAATTATTCTGTCGAAGAGTTTACAAAACGCATTCTTAACGGGTAA

Structures

Toxin

• AlphaFold DB: B0UV74