Detailed information of TA system TA136870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 1651117..1651849
• Replicon: chromosome
• Accession: NZ_CP042988
• Organism: Histophilus somni strain UOC-KLM-ATR-09

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: FWK49_RS07330
• Protein ID: WP_075294106.1
• Coordinates: 1651117..1651584 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: FWK49_RS07335
• Protein ID: WP_011609927.1
• Coordinates: 1651586..1651849 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK49_RS07290	1646195..1646641	+	447	WP_075293401.1	hypothetical protein	-
FWK49_RS07295	1646660..1647589	-	930	WP_075293400.1	hypothetical protein	-
FWK49_RS07300	1647845..1648981	-	1137	WP_075319813.1	transposase	-
FWK49_RS07305	1649028..1649444	+	417	WP_075319814.1	IS200/IS605 family transposase	-
FWK49_RS07310	1649521..1649781	+	261	Protein_1402	hemophilus-specific protein	-
FWK49_RS07315	1649913..1650167	+	255	WP_075294104.1	DUF4160 domain-containing protein	-
FWK49_RS07320	1650136..1650438	+	303	WP_075294105.1	DUF2442 domain-containing protein	-
FWK49_RS07330	1651117..1651584	-	468	WP_075294106.1	GNAT family N-acetyltransferase	Toxin
FWK49_RS07335	1651586..1651849	-	264	WP_011609927.1	DUF1778 domain-containing protein	Antitoxin
FWK49_RS07340	1651987..1652298	-	312	WP_075294107.1	hypothetical protein	-
FWK49_RS07345	1652298..1652552	-	255	WP_075294108.1	DUF1778 domain-containing protein	-
FWK49_RS09730	1652706..1653362	-	657	WP_157665518.1	hypothetical protein	-
FWK49_RS07355	1654028..1656316	-	2289	WP_075321885.1	hypothetical protein	-
FWK49_RS07360	1656379..1656741	-	363	WP_135026582.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1649028..1649444	416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-86)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17344.33 Da
• Isoelectric Point: 10.5585

>T136870 WP_075294106.1 NZ_CP042988:c1651584-1651117 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Nucleotide

• Length: 468 bp

>T136870 NZ_CP042988:c1651584-1651117 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAGAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCATCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCACCAATTGATGATATGTTATTGATGTTGAAGTTATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9906.35 Da
• Isoelectric Point: 5.6388

>AT136870 WP_011609927.1 NZ_CP042988:c1651849-1651586 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Nucleotide

• Length: 264 bp

>AT136870 NZ_CP056275:c4638441-4638199 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA