Detailed information of TA system TA136868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 481824..482305
• Replicon: chromosome
• Accession: NZ_CP042988
• Organism: Histophilus somni strain UOC-KLM-ATR-09

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FWK49_RS02235
• Protein ID: WP_168694031.1
• Coordinates: 481824..482084 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FWK49_RS02240
• Protein ID: WP_075294306.1
• Coordinates: 482084..482305 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK49_RS02210	477884..479224	+	1341	WP_075294311.1	PTS sugar transporter subunit IIC	-
FWK49_RS02215	479290..479709	+	420	WP_075294310.1	pseudouridine synthase	-
FWK49_RS02220	479888..480079	+	192	WP_075294309.1	hypothetical protein	-
FWK49_RS02225	480195..481646	+	1452	WP_075294308.1	DUF560 domain-containing protein	-
FWK49_RS02230	481710..481820	+	111	Protein_428	CAAX protease	-
FWK49_RS02235	481824..482084	-	261	WP_168694031.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FWK49_RS02240	482084..482305	-	222	WP_075294306.1	CopG family transcriptional regulator	Antitoxin
FWK49_RS02250	482741..484660	+	1920	WP_136122078.1	transferrin-binding protein-like solute binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10063.70 Da
• Isoelectric Point: 9.9542

>T136868 WP_168694031.1 NZ_CP042988:c482084-481824 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTGNRSGEWRYRVGDYRIICDIRDSELIIFALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T136868 NZ_CP042988:c482084-481824 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAACTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATATTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8543.65 Da
• Isoelectric Point: 4.4284

>AT136868 WP_075294306.1 NZ_CP042988:c482305-482084 [Histophilus somni]
MAISIRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEEYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT136868 NZ_CP042988:c482305-482084 [Histophilus somni]
ATGGCTATTTCAATAAGATTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGAAT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA