Detailed information of TA system TA136867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 1651136..1651868
• Replicon: chromosome
• Accession: NZ_CP042987
• Organism: Histophilus somni strain UOC-KLM-ATR-08

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: FWK48_RS07465
• Protein ID: WP_011609926.1
• Coordinates: 1651136..1651603 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: FWK48_RS07470
• Protein ID: WP_011609927.1
• Coordinates: 1651605..1651868 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK48_RS07425	1646213..1646659	+	447	WP_075293401.1	hypothetical protein	-
FWK48_RS07430	1646678..1647607	-	930	WP_075293400.1	hypothetical protein	-
FWK48_RS07435	1647863..1648999	-	1137	WP_075319813.1	transposase	-
FWK48_RS07440	1649046..1649463	+	418	Protein_1433	IS200/IS605 family transposase	-
FWK48_RS07445	1649540..1649800	+	261	Protein_1434	hemophilus-specific protein	-
FWK48_RS07450	1649932..1650186	+	255	WP_075294104.1	DUF4160 domain-containing protein	-
FWK48_RS07455	1650155..1650457	+	303	WP_075294105.1	DUF2442 domain-containing protein	-
FWK48_RS07460	1650553..1650786	+	234	WP_011609925.1	hypothetical protein	-
FWK48_RS07465	1651136..1651603	-	468	WP_011609926.1	GNAT family N-acetyltransferase	Toxin
FWK48_RS07470	1651605..1651868	-	264	WP_011609927.1	DUF1778 domain-containing protein	Antitoxin
FWK48_RS07475	1652006..1652317	-	312	WP_075294107.1	hypothetical protein	-
FWK48_RS07480	1652317..1652571	-	255	WP_075294108.1	DUF1778 domain-containing protein	-
FWK48_RS09905	1652725..1653381	-	657	WP_157665518.1	hypothetical protein	-
FWK48_RS07490	1654047..1656335	-	2289	WP_147603859.1	hypothetical protein	-
FWK48_RS07495	1656398..1656760	-	363	WP_135026582.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-86)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17307.31 Da
• Isoelectric Point: 10.5068

>T136867 WP_011609926.1 NZ_CP042987:c1651603-1651136 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALKNRQNRASRTFVICNENVVVGFYALAAGSVTQRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Nucleotide

• Length: 468 bp

>T136867 NZ_CP042987:c1651603-1651136 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAAAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCAGCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCACCAATTGATGATATGTTATTGATGTTGAAGTTATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9906.35 Da
• Isoelectric Point: 5.6388

>AT136867 WP_011609927.1 NZ_CP042987:c1651868-1651605 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Nucleotide

• Length: 264 bp

>AT136867 NZ_CP056275:c2585837-2585571 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACATGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA