Detailed information of TA system TA136866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1168291..1168849
• Replicon: chromosome
• Accession: NZ_CP042987
• Organism: Histophilus somni strain UOC-KLM-ATR-08

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UUG7
• Locus tag: FWK48_RS05225
• Protein ID: WP_012340589.1
• Coordinates: 1168577..1168849 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0UUG6
• Locus tag: FWK48_RS05220
• Protein ID: WP_012340588.1
• Coordinates: 1168291..1168584 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK48_RS05195	1164535..1165224	-	690	WP_075293923.1	CidB/LrgB family autolysis modulator	-
FWK48_RS05200	1165221..1165637	-	417	WP_075293924.1	CidA/LrgA family protein	-
FWK48_RS05205	1165763..1166266	+	504	WP_041604213.1	thermonuclease family protein	-
FWK48_RS05210	1166256..1167455	+	1200	WP_136121312.1	cysteine desulfurase	-
FWK48_RS05215	1167452..1167832	+	381	WP_136121313.1	SufE family protein	-
FWK48_RS05220	1168291..1168584	+	294	WP_012340588.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FWK48_RS05225	1168577..1168849	+	273	WP_012340589.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FWK48_RS05230	1168934..1170076	-	1143	WP_136121315.1	porin	-
FWK48_RS05235	1170514..1170795	+	282	WP_012340591.1	virulence factor	-
FWK48_RS05240	1170994..1171293	+	300	WP_012340592.1	DUF1778 domain-containing protein	-
FWK48_RS05245	1171283..1171789	+	507	WP_012340594.1	GNAT family N-acetyltransferase	-
FWK48_RS05250	1171813..1173009	-	1197	WP_012340595.1	lipopolysaccharide assembly protein LapB	-
FWK48_RS05255	1173019..1173303	-	285	WP_012340596.1	DUF1049 domain-containing protein	-
FWK48_RS05260	1173423..1173707	-	285	WP_011609129.1	integration host factor subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-72)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10472.11 Da
• Isoelectric Point: 6.9669

>T136866 WP_012340589.1 NZ_CP042987:1168577-1168849 [Histophilus somni]
MAKRKFDMAKSFKRDLRKHYLALVGEAWAEISNCLLNDLPIPEKYQDHPLKGDKSGFRDCHVKPDLVLIYKIVDDVVELH
YLDSHSEIFG

Nucleotide

• Length: 273 bp

>T136866 NZ_CP042987:1168577-1168849 [Histophilus somni]
ATGGCTAAACGCAAATTTGATATGGCAAAATCTTTTAAACGTGATTTGAGAAAACATTACTTGGCTTTAGTCGGCGAAGC
ATGGGCAGAGATTTCAAACTGTCTTTTGAATGACTTGCCAATTCCTGAAAAGTATCAAGATCACCCGCTTAAAGGCGATA
AATCAGGGTTTCGAGACTGCCATGTCAAACCGGATTTAGTGTTGATATACAAAATCGTTGATGATGTTGTGGAGTTACAT
TACCTTGATAGCCATAGCGAAATTTTTGGCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11279.60 Da
• Isoelectric Point: 4.7815

>AT136866 WP_012340588.1 NZ_CP042987:1168291-1168584 [Histophilus somni]
MDYTNFNMRLDNDLRGRAYPILEQYGLTPSQAVRMFFNQIAQTGKIPLSFDWAENQTLTPKAAARLRQTEQEFANGEFER
FYSLDELNQAIKEISHG

Nucleotide

• Length: 294 bp

>AT136866 NZ_CP042987:1168291-1168584 [Histophilus somni]
ATGGATTATACAAATTTTAATATGCGACTTGATAACGACTTGCGTGGACGGGCTTATCCTATTTTGGAGCAGTATGGATT
GACGCCAAGTCAAGCGGTAAGAATGTTTTTTAATCAGATTGCACAAACCGGTAAAATACCCTTGTCGTTTGATTGGGCGG
AAAATCAAACTTTAACCCCAAAAGCAGCCGCACGGTTACGCCAAACTGAGCAGGAATTCGCCAATGGCGAATTTGAACGC
TTTTATAGCCTAGATGAACTCAATCAAGCGATAAAGGAGATCTCGCATGGCTAA

Structures

Toxin

• AlphaFold DB: B0UUG7

Antitoxin

• AlphaFold DB: B0UUG6