Detailed information of TA system TA136865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 481897..482378
• Replicon: chromosome
• Accession: NZ_CP042987
• Organism: Histophilus somni strain UOC-KLM-ATR-08

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FWK48_RS02255
• Protein ID: WP_168693910.1
• Coordinates: 481897..482157 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FWK48_RS02260
• Protein ID: WP_136121587.1
• Coordinates: 482157..482378 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK48_RS02230	477960..479300	+	1341	WP_136121592.1	PTS sugar transporter subunit IIC	-
FWK48_RS02235	479366..479785	+	420	WP_136121591.1	pseudouridine synthase	-
FWK48_RS02240	479880..480155	+	276	WP_136121590.1	hypothetical protein	-
FWK48_RS02245	480262..481719	+	1458	WP_136121589.1	DUF560 domain-containing protein	-
FWK48_RS02255	481897..482157	-	261	WP_168693910.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FWK48_RS02260	482157..482378	-	222	WP_136121587.1	CopG family transcriptional regulator	Antitoxin
FWK48_RS02265	482441..482539	+	99	Protein_438	IS200/IS605 family transposase	-
FWK48_RS02270	482812..484738	+	1927	Protein_439	transferrin-binding protein-like solute binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10028.74 Da
• Isoelectric Point: 10.2656

>T136865 WP_168693910.1 NZ_CP042987:c482157-481897 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTGNRSGEWRYRVGDYRIICDIRDSKLIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T136865 NZ_CP042987:c482157-481897 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAATTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTAAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8529.63 Da
• Isoelectric Point: 4.4142

>AT136865 WP_136121587.1 NZ_CP042987:c482378-482157 [Histophilus somni]
MAISIRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEDYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT136865 NZ_CP042987:c482378-482157 [Histophilus somni]
ATGGCTATTTCAATAAGATTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGACT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA