Detailed information of TA system TA136864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 1651105..1651837
• Replicon: chromosome
• Accession: NZ_CP042986
• Organism: Histophilus somni strain UOC-KLM-ATR-07

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: FWK47_RS07305
• Protein ID: WP_075294106.1
• Coordinates: 1651105..1651572 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: FWK47_RS07310
• Protein ID: WP_011609927.1
• Coordinates: 1651574..1651837 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK47_RS07265	1646183..1646629	+	447	WP_075293401.1	hypothetical protein	-
FWK47_RS07270	1646648..1647577	-	930	WP_075293400.1	hypothetical protein	-
FWK47_RS07275	1647833..1648969	-	1137	WP_075319813.1	transposase	-
FWK47_RS07280	1649016..1649432	+	417	WP_075319814.1	IS200/IS605 family transposase	-
FWK47_RS07285	1649509..1649769	+	261	Protein_1398	hemophilus-specific protein	-
FWK47_RS07290	1649901..1650155	+	255	WP_075294104.1	DUF4160 domain-containing protein	-
FWK47_RS07295	1650124..1650426	+	303	WP_075294105.1	DUF2442 domain-containing protein	-
FWK47_RS07300	1650522..1650755	+	234	WP_011609925.1	hypothetical protein	-
FWK47_RS07305	1651105..1651572	-	468	WP_075294106.1	GNAT family N-acetyltransferase	Toxin
FWK47_RS07310	1651574..1651837	-	264	WP_011609927.1	DUF1778 domain-containing protein	Antitoxin
FWK47_RS07315	1651975..1652286	-	312	WP_075294107.1	hypothetical protein	-
FWK47_RS07320	1652286..1652540	-	255	WP_075294108.1	DUF1778 domain-containing protein	-
FWK47_RS09710	1652694..1653350	-	657	WP_157665518.1	hypothetical protein	-
FWK47_RS07330	1654016..1656304	-	2289	WP_075321885.1	hypothetical protein	-
FWK47_RS07335	1656367..1656729	-	363	WP_135026582.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1649016..1649432	416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-86)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17344.33 Da
• Isoelectric Point: 10.5585

>T136864 WP_075294106.1 NZ_CP042986:c1651572-1651105 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Nucleotide

• Length: 468 bp

>T136864 NZ_CP042986:c1651572-1651105 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAGAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCATCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCACCAATTGATGATATGTTATTGATGTTGAAGTTATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9906.35 Da
• Isoelectric Point: 5.6388

>AT136864 WP_011609927.1 NZ_CP042986:c1651837-1651574 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Nucleotide

• Length: 264 bp

>AT136864 NZ_CP056275:355325-355624 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA