Detailed information of TA system TA136861

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 1651119..1651851
• Replicon: chromosome
• Accession: NZ_CP042985
• Organism: Histophilus somni strain UOC-KLM-ATR-06

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: FWK46_RS07320
• Protein ID: WP_075294106.1
• Coordinates: 1651119..1651586 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: FWK46_RS07325
• Protein ID: WP_011609927.1
• Coordinates: 1651588..1651851 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK46_RS07280	1646197..1646643	+	447	WP_075293401.1	hypothetical protein	-
FWK46_RS07285	1646662..1647591	-	930	WP_075293400.1	hypothetical protein	-
FWK46_RS07290	1647847..1648983	-	1137	WP_075319813.1	transposase	-
FWK46_RS07295	1649030..1649446	+	417	WP_075319814.1	IS200/IS605 family transposase	-
FWK46_RS07300	1649523..1649783	+	261	Protein_1402	hemophilus-specific protein	-
FWK46_RS07305	1649915..1650169	+	255	WP_075294104.1	DUF4160 domain-containing protein	-
FWK46_RS07310	1650138..1650440	+	303	WP_075294105.1	DUF2442 domain-containing protein	-
FWK46_RS07315	1650536..1650769	+	234	WP_011609925.1	hypothetical protein	-
FWK46_RS07320	1651119..1651586	-	468	WP_075294106.1	GNAT family N-acetyltransferase	Toxin
FWK46_RS07325	1651588..1651851	-	264	WP_011609927.1	DUF1778 domain-containing protein	Antitoxin
FWK46_RS07330	1651989..1652300	-	312	WP_075294107.1	hypothetical protein	-
FWK46_RS07335	1652300..1652554	-	255	WP_075294108.1	DUF1778 domain-containing protein	-
FWK46_RS09725	1652708..1653364	-	657	WP_157665518.1	hypothetical protein	-
FWK46_RS07345	1654030..1656318	-	2289	WP_075321885.1	hypothetical protein	-
FWK46_RS07350	1656381..1656743	-	363	WP_135026582.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1649030..1649446	416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-86)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17344.33 Da
• Isoelectric Point: 10.5585

>T136861 WP_075294106.1 NZ_CP042985:c1651586-1651119 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Nucleotide

• Length: 468 bp

>T136861 NZ_CP042985:c1651586-1651119 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAGAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCATCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCACCAATTGATGATATGTTATTGATGTTGAAGTTATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9906.35 Da
• Isoelectric Point: 5.6388

>AT136861 WP_011609927.1 NZ_CP042985:c1651851-1651588 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Nucleotide

• Length: 264 bp

>AT136861 NZ_CP056260:4128228-4128602 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGATGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG