Detailed information of TA system TA136859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 481844..482325
• Replicon: chromosome
• Accession: NZ_CP042985
• Organism: Histophilus somni strain UOC-KLM-ATR-06

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FWK46_RS02245
• Protein ID: WP_075294307.1
• Coordinates: 481844..482104 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FWK46_RS02250
• Protein ID: WP_075294306.1
• Coordinates: 482104..482325 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK46_RS02215	477899..479239	+	1341	WP_075294311.1	PTS sugar transporter subunit IIC	-
FWK46_RS02220	479305..479724	+	420	WP_075294310.1	pseudouridine synthase	-
FWK46_RS02225	479903..480094	+	192	WP_075294309.1	hypothetical protein	-
FWK46_RS02230	480210..481181	+	972	WP_147630921.1	DUF560 domain-containing protein	-
FWK46_RS02240	481730..481840	+	111	Protein_430	CAAX protease	-
FWK46_RS02245	481844..482104	-	261	WP_075294307.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FWK46_RS02250	482104..482325	-	222	WP_075294306.1	CopG family transcriptional regulator	Antitoxin
FWK46_RS02260	482761..484682	+	1922	Protein_433	transferrin-binding protein-like solute binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10029.68 Da
• Isoelectric Point: 9.9542

>T136859 WP_075294307.1 NZ_CP042985:c482104-481844 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTGNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T136859 NZ_CP042985:c482104-481844 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAACTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8543.65 Da
• Isoelectric Point: 4.4284

>AT136859 WP_075294306.1 NZ_CP042985:c482325-482104 [Histophilus somni]
MAISIRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEEYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT136859 NZ_CP056260:c2075970-2075932 [Klebsiella aerogenes]
TAATAGATAAAAAGAGACCGAACACGATTCCTGTATTCG