Detailed information of TA system TA136858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1700262..1700743
• Replicon: chromosome
• Accession: NZ_CP042984
• Organism: Histophilus somni strain UOC-KLM-ATR-03

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FWK44_RS07975
• Protein ID: WP_165942816.1
• Coordinates: 1700483..1700743 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FWK44_RS07970
• Protein ID: WP_011608602.1
• Coordinates: 1700262..1700483 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK44_RS07960	1697929..1699825	-	1897	Protein_1534	transferrin-binding protein-like solute binding protein	-
FWK44_RS07965	1700101..1700199	-	99	Protein_1535	IS200/IS605 family transposase	-
FWK44_RS07970	1700262..1700483	+	222	WP_011608602.1	hypothetical protein	Antitoxin
FWK44_RS07975	1700483..1700743	+	261	WP_165942816.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FWK44_RS07985	1700922..1702376	-	1455	WP_133098755.1	DUF560 domain-containing protein	-
FWK44_RS07990	1702861..1703280	-	420	WP_075321652.1	pseudouridine synthase	-
FWK44_RS07995	1703346..1704686	-	1341	WP_075321653.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10128.82 Da
• Isoelectric Point: 10.1365

>T136858 WP_165942816.1 NZ_CP042984:1700483-1700743 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTRNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T136858 NZ_CP042984:1700483-1700743 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAATTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTAGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.60 Da
• Isoelectric Point: 4.4142

>AT136858 WP_011608602.1 NZ_CP042984:1700262-1700483 [Histophilus somni]
MAISVRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEDYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT136858 NZ_CP042984:1700262-1700483 [Histophilus somni]
ATGGCTATTTCAGTAAGACTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGACT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA