Detailed information of TA system TA136856

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 461418..462150
• Replicon: chromosome
• Accession: NZ_CP042984
• Organism: Histophilus somni strain UOC-KLM-ATR-03

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: FWK44_RS02370
• Protein ID: WP_011609926.1
• Coordinates: 461683..462150 (+)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: FWK44_RS02365
• Protein ID: WP_011609927.1
• Coordinates: 461418..461681 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK44_RS02340	456525..456887	+	363	WP_135026582.1	hypothetical protein	-
FWK44_RS02345	456962..459235	+	2274	WP_132995746.1	hypothetical protein	-
FWK44_RS10255	459900..460589	+	690	WP_187376353.1	hypothetical protein	-
FWK44_RS02355	460710..460968	+	259	Protein_454	DUF1778 domain-containing protein	-
FWK44_RS02360	461044..461280	+	237	WP_011609928.1	hypothetical protein	-
FWK44_RS02365	461418..461681	+	264	WP_011609927.1	DUF1778 domain-containing protein	Antitoxin
FWK44_RS02370	461683..462150	+	468	WP_011609926.1	GNAT family N-acetyltransferase	Toxin
FWK44_RS02380	462829..463131	-	303	WP_147590449.1	DUF2442 domain-containing protein	-
FWK44_RS02385	463100..463354	-	255	WP_075294104.1	DUF4160 domain-containing protein	-
FWK44_RS02390	463486..463775	-	290	Protein_460	hemophilus-specific protein	-
FWK44_RS02395	463822..464238	-	417	WP_075319814.1	IS200/IS605 family transposase	-
FWK44_RS02400	464285..465421	+	1137	WP_075319813.1	transposase	-
FWK44_RS02405	465677..466621	+	945	WP_147590450.1	hypothetical protein	-
FWK44_RS02410	466627..467073	-	447	WP_011609888.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	463822..464238	416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-86)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17307.31 Da
• Isoelectric Point: 10.5068

>T136856 WP_011609926.1 NZ_CP042984:461683-462150 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALKNRQNRASRTFVICNENVVVGFYALAAGSVTQRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Nucleotide

• Length: 468 bp

>T136856 NZ_CP042984:461683-462150 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAAAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCAGCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCGCCAATTGATGATATGTTATTGATGTTGAAGTTGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9906.35 Da
• Isoelectric Point: 5.6388

>AT136856 WP_011609927.1 NZ_CP042984:461418-461681 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Nucleotide

• Length: 264 bp

>AT136856 NZ_CP056260:840982-841248 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGATAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA