Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 461044..461681 Replicon chromosome
Accession NZ_CP042984
Organism Histophilus somni strain UOC-KLM-ATR-03

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FWK44_RS02360 Protein ID WP_011609928.1
Coordinates 461044..461280 (+) Length 79 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag FWK44_RS02365 Protein ID WP_011609927.1
Coordinates 461418..461681 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FWK44_RS02335 456104..456523 + 420 WP_178384271.1 hypothetical protein -
FWK44_RS02340 456525..456887 + 363 WP_135026582.1 hypothetical protein -
FWK44_RS02345 456962..459235 + 2274 WP_132995746.1 hypothetical protein -
FWK44_RS10255 459900..460589 + 690 WP_187376353.1 hypothetical protein -
FWK44_RS02355 460710..460968 + 259 Protein_454 DUF1778 domain-containing protein -
FWK44_RS02360 461044..461280 + 237 WP_011609928.1 hypothetical protein Toxin
FWK44_RS02365 461418..461681 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
FWK44_RS02370 461683..462150 + 468 WP_011609926.1 GNAT family N-acetyltransferase -
FWK44_RS02380 462829..463131 - 303 WP_147590449.1 DUF2442 domain-containing protein -
FWK44_RS02385 463100..463354 - 255 WP_075294104.1 DUF4160 domain-containing protein -
FWK44_RS02390 463486..463775 - 290 Protein_460 hemophilus-specific protein -
FWK44_RS02395 463822..464238 - 417 WP_075319814.1 IS200/IS605 family transposase -
FWK44_RS02400 464285..465421 + 1137 WP_075319813.1 transposase -
FWK44_RS02405 465677..466621 + 945 WP_147590450.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 463822..464238 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 8873.59 Da        Isoelectric Point: 10.4575

>T136855 WP_011609928.1 NZ_CP042984:461044-461280 [Histophilus somni]
MNLYLQKQVSQDIKRRIAPCFTVIDENKRILGYYTLASTSIPLVSLPENLKKKLPRYPSVPAVLLGRLAVDKQVSIFI

Download         Length: 237 bp

>T136855 NZ_CP042984:461044-461280 [Histophilus somni]
TTGAATCTCTATTTACAAAAACAGGTTTCACAAGATATCAAAAGGCGTATTGCTCCTTGCTTTACTGTCATTGATGAAAA
TAAACGTATTTTAGGCTACTATACTTTAGCCTCAACAAGCATTCCTCTTGTCTCTCTCCCTGAGAACCTTAAGAAAAAAT
TACCCCGTTATCCTAGTGTTCCGGCGGTTTTACTTGGACGCTTAGCCGTTGACAAGCAAGTCTCAATATTCATTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT136855 WP_011609927.1 NZ_CP042984:461418-461681 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT136855 NZ_CP056260:77438-77884 [Klebsiella aerogenes]
ATGACTAAACTGAACCTTCCGGACCCGCTGGAGAGTGAACTTGCCCAGCGCGGGCAGCGTGAGCTGGCGGCATACCTTTC
TACTCATCTTGAAACGCAGCGTATTGCGATTGTGGGTGAAGATGACAAAACTCATACCATTGAGTTGCCAACCAGCGCTC
TGACTATGCTGATGGAGATCCTTGGGGAATTGGCTTGTGGCAACGCGGTGCAGATTGTTCCTGTTCATGCTGAACTCACC
ACCCAGGAAGCAGCGAATATACTCAATGTTTCTCGTCCGCATATGGTTAAACTGCTGGAAGCGAGGAAGCTTCCATTTCA
TAAAACTGGACGCCATCGCCGGGTTCTGTTTGCCGATCTGATGGAGTATAAAAAACGTAGGGAACAGGAAAGCCTGGACG
CGATGCAAGCGCTGGCGGATCAGGCGCAGGACTTAGGGATGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References