Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 1651596..1652233 Replicon chromosome
Accession NZ_CP042983
Organism Histophilus somni strain UOC-KLM-ATR-01

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FWK43_RS07425 Protein ID WP_011609928.1
Coordinates 1651997..1652233 (-) Length 79 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag FWK43_RS07420 Protein ID WP_011609927.1
Coordinates 1651596..1651859 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FWK43_RS07380 1646659..1647600 - 942 WP_148635115.1 hypothetical protein -
FWK43_RS07385 1647856..1648992 - 1137 WP_147611117.1 transposase -
FWK43_RS07390 1649039..1649455 + 417 WP_075319814.1 IS200/IS605 family transposase -
FWK43_RS07395 1649528..1649791 + 264 Protein_1425 hemophilus-specific protein -
FWK43_RS07400 1649923..1650177 + 255 WP_075294104.1 DUF4160 domain-containing protein -
FWK43_RS07405 1650146..1650448 + 303 WP_147611116.1 DUF2442 domain-containing protein -
FWK43_RS07415 1651127..1651594 - 468 WP_011609926.1 GNAT family N-acetyltransferase -
FWK43_RS07420 1651596..1651859 - 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
FWK43_RS07425 1651997..1652233 - 237 WP_011609928.1 hypothetical protein Toxin
FWK43_RS07430 1652309..1652566 - 258 WP_148635117.1 DUF1778 domain-containing protein -
FWK43_RS09895 1652687..1653376 - 690 WP_187388463.1 hypothetical protein -
FWK43_RS07440 1654041..1656314 - 2274 WP_132995746.1 hypothetical protein -
FWK43_RS07445 1656387..1656749 - 363 WP_135026582.1 hypothetical protein -
FWK43_RS07450 1656751..1657170 - 420 WP_178384271.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1649039..1649455 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 8873.59 Da        Isoelectric Point: 10.4575

>T136854 WP_011609928.1 NZ_CP042983:c1652233-1651997 [Histophilus somni]
MNLYLQKQVSQDIKRRIAPCFTVIDENKRILGYYTLASTSIPLVSLPENLKKKLPRYPSVPAVLLGRLAVDKQVSIFI

Download         Length: 237 bp

>T136854 NZ_CP056259:c3580-3248 [Citrobacter freundii]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAGCAAAGTGGAAAACGTCCGGTGCTTAT
CGTTTCTCCAGCATCATTTAATAAGTTCACCCGGCTACCTGTTGTCGTTCCCGTCACTAGCGGCGGAAACTTTGCCCGCG
CAGCCGGTTTTACCGTCTCCCTGGACGGTGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAACCCAGAACGATT
GATATGGGGGCTCGGAACGGTAAGTGTCTGGAACGTATACCCGAAGCTGTTGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTAAGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT136854 WP_011609927.1 NZ_CP042983:c1651859-1651596 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT136854 NZ_CP042983:c1651859-1651596 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References