Detailed information of TA system TA136853

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 1651127..1651859
• Replicon: chromosome
• Accession: NZ_CP042983
• Organism: Histophilus somni strain UOC-KLM-ATR-01

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: FWK43_RS07415
• Protein ID: WP_011609926.1
• Coordinates: 1651127..1651594 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: FWK43_RS07420
• Protein ID: WP_011609927.1
• Coordinates: 1651596..1651859 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK43_RS07375	1646207..1646653	+	447	WP_011609888.1	hypothetical protein	-
FWK43_RS07380	1646659..1647600	-	942	WP_148635115.1	hypothetical protein	-
FWK43_RS07385	1647856..1648992	-	1137	WP_147611117.1	transposase	-
FWK43_RS07390	1649039..1649455	+	417	WP_075319814.1	IS200/IS605 family transposase	-
FWK43_RS07395	1649528..1649791	+	264	Protein_1425	hemophilus-specific protein	-
FWK43_RS07400	1649923..1650177	+	255	WP_075294104.1	DUF4160 domain-containing protein	-
FWK43_RS07405	1650146..1650448	+	303	WP_147611116.1	DUF2442 domain-containing protein	-
FWK43_RS07415	1651127..1651594	-	468	WP_011609926.1	GNAT family N-acetyltransferase	Toxin
FWK43_RS07420	1651596..1651859	-	264	WP_011609927.1	DUF1778 domain-containing protein	Antitoxin
FWK43_RS07425	1651997..1652233	-	237	WP_011609928.1	hypothetical protein	-
FWK43_RS07430	1652309..1652566	-	258	WP_148635117.1	DUF1778 domain-containing protein	-
FWK43_RS09895	1652687..1653376	-	690	WP_187388463.1	hypothetical protein	-
FWK43_RS07440	1654041..1656314	-	2274	WP_132995746.1	hypothetical protein	-
FWK43_RS07445	1656387..1656749	-	363	WP_135026582.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1649039..1649455	416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-86)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17307.31 Da
• Isoelectric Point: 10.5068

>T136853 WP_011609926.1 NZ_CP042983:c1651594-1651127 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALKNRQNRASRTFVICNENVVVGFYALAAGSVTQRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Nucleotide

• Length: 468 bp

>T136853 NZ_CP042983:c1651594-1651127 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAAAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCAGCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCGCCAATTGATGATATGTTATTGATGTTGAAGTTGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9906.35 Da
• Isoelectric Point: 5.6388

>AT136853 WP_011609927.1 NZ_CP042983:c1651859-1651596 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Nucleotide

• Length: 264 bp

>AT136853 NZ_CP042983:c1651859-1651596 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA