Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1168293..1168851 Replicon chromosome
Accession NZ_CP042983
Organism Histophilus somni strain UOC-KLM-ATR-01

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FWK43_RS05195 Protein ID WP_148635061.1
Coordinates 1168579..1168851 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FWK43_RS05190 Protein ID WP_132994429.1
Coordinates 1168293..1168586 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FWK43_RS05165 1164534..1165223 - 690 WP_075293923.1 CidB/LrgB family autolysis modulator -
FWK43_RS05170 1165220..1165636 - 417 WP_075293924.1 CidA/LrgA family protein -
FWK43_RS05175 1165762..1166265 + 504 WP_041604213.1 thermonuclease family protein -
FWK43_RS05180 1166255..1167454 + 1200 WP_132994432.1 cysteine desulfurase -
FWK43_RS05185 1167451..1167831 + 381 WP_075293926.1 SufE family protein -
FWK43_RS05190 1168293..1168586 + 294 WP_132994429.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FWK43_RS05195 1168579..1168851 + 273 WP_148635061.1 type II toxin-antitoxin system YafQ family toxin Toxin
FWK43_RS05200 1168936..1169499 - 564 WP_148635063.1 porin -
FWK43_RS05205 1169514..1170077 - 564 Protein_999 porin -
FWK43_RS05210 1170516..1170797 + 282 WP_132994427.1 virulence factor -
FWK43_RS05215 1170996..1171295 + 300 WP_012340592.1 DUF1778 domain-containing protein -
FWK43_RS05220 1171285..1171791 + 507 WP_075293929.1 GNAT family N-acetyltransferase -
FWK43_RS05225 1171815..1173011 - 1197 WP_075293930.1 lipopolysaccharide assembly protein LapB -
FWK43_RS05230 1173021..1173305 - 285 WP_012340596.1 DUF1049 domain-containing protein -
FWK43_RS05235 1173425..1173709 - 285 WP_075321052.1 integration host factor subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(13-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-59)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10368.06 Da        Isoelectric Point: 6.6267

>T136852 WP_148635061.1 NZ_CP042983:1168579-1168851 [Histophilus somni]
MAKRNCEITLPCKRDLRKHYLALVGEAWAEISNCLLNDLPIPEKYQDHPLKGDKSGFRDCHVKPDLVLIKEILNVIVELH
YLDSHSEIFG

Download         Length: 273 bp

>T136852 NZ_CP042983:1168579-1168851 [Histophilus somni]
ATGGCTAAACGTAATTGTGAAATTACATTACCTTGTAAACGTGATTTGAGAAAACATTACTTGGCTTTAGTCGGCGAAGC
ATGGGCAGAGATTTCAAACTGTCTTTTGAATGACTTGCCAATTCCTGAAAAGTATCAAGATCACCCGCTTAAAGGCGATA
AATCAGGCTTTCGAGACTGCCATGTCAAACCGGATTTAGTGTTGATAAAGGAGATCCTAAACGTAATTGTGGAGTTACAT
TACCTTGATAGCCATAGCGAAATTTTTGGCTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11329.67 Da        Isoelectric Point: 5.1053

>AT136852 WP_132994429.1 NZ_CP042983:1168293-1168586 [Histophilus somni]
MDYTNFNMRLDNDLRRRAYPILEQYGLTPSQAVRMFFNQIAQTGKIPLSFDWAENQTLTPKAAARLRQTEQEFANGEFER
FNSLDELNQAIKEISHG

Download         Length: 294 bp

>AT136852 NZ_CP042983:1168293-1168586 [Histophilus somni]
ATGGATTATACAAATTTTAATATGCGACTTGATAACGACTTGCGTAGACGAGCTTATCCTATTTTGGAGCAGTATGGATT
GACACCAAGTCAAGCGGTAAGAATGTTTTTTAATCAGATTGCACAAACCGGTAAAATACCCTTGTCGTTTGATTGGGCGG
AAAATCAAACGTTAACCCCAAAAGCAGCAGCACGATTACGCCAAACTGAGCAGGAATTCGCCAATGGCGAATTTGAACGC
TTTAATAGCCTAGATGAACTCAATCAAGCGATAAAGGAGATTTCGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References