Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2965608..2966262 Replicon chromosome
Accession NZ_CP042980
Organism Shigella flexneri Y strain PE577

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag FW259_RS15410 Protein ID WP_000244767.1
Coordinates 2965608..2966015 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag FW259_RS15415 Protein ID WP_000354044.1
Coordinates 2965996..2966262 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FW259_RS15390 2961565..2963298 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
FW259_RS15395 2963304..2964014 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FW259_RS15400 2964039..2964935 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
FW259_RS15405 2965047..2965568 + 522 WP_001055867.1 flavodoxin FldB -
FW259_RS15410 2965608..2966015 - 408 WP_000244767.1 protein YgfX Toxin
FW259_RS15415 2965996..2966262 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
FW259_RS15420 2966505..2967485 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
FW259_RS15425 2967681..2968340 - 660 WP_000250274.1 hemolysin III family protein -
FW259_RS15430 2968504..2968814 - 311 Protein_2933 ASCH domain-containing protein -
FW259_RS15435 2968859..2970292 + 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
FW259_RS15440 2970349..2971092 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T136847 WP_000244767.1 NZ_CP042980:c2966015-2965608 [Shigella flexneri Y]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T136847 NZ_CP042980:c2966015-2965608 [Shigella flexneri Y]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT136847 WP_000354044.1 NZ_CP042980:c2966262-2965996 [Shigella flexneri Y]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT136847 NZ_CP042980:c2966262-2965996 [Shigella flexneri Y]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References