136829

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5050015..5050640 Replicon chromosome
Accession NZ_CP042977
Organism Klebsiella pneumoniae strain KPN55602

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag FVE92_RS26545 Protein ID WP_002882817.1
Coordinates 5050015..5050398 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag FVE92_RS26550 Protein ID WP_004150355.1
Coordinates 5050398..5050640 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE92_RS26530 5047381..5048283 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
FVE92_RS26535 5048280..5048915 + 636 WP_117103009.1 formate dehydrogenase cytochrome b556 subunit -
FVE92_RS26540 5048912..5049841 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
FVE92_RS26545 5050015..5050398 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
FVE92_RS26550 5050398..5050640 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
FVE92_RS26555 5050845..5051762 + 918 WP_004213381.1 alpha/beta hydrolase -
FVE92_RS26560 5051777..5052718 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
FVE92_RS26565 5052763..5053200 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
FVE92_RS26570 5053197..5054057 - 861 WP_004146232.1 virulence factor BrkB family protein -
FVE92_RS26575 5054051..5054650 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T136829 WP_002882817.1 NZ_CP042977:c5050398-5050015 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T136829 NZ_CP042977:c5050398-5050015 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACTTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT136829 WP_004150355.1 NZ_CP042977:c5050640-5050398 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT136829 NZ_CP042977:c5050640-5050398 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References