136825

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3849171..3849790 Replicon chromosome
Accession NZ_CP042977
Organism Klebsiella pneumoniae strain KPN55602

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FVE92_RS20755 Protein ID WP_002892050.1
Coordinates 3849572..3849790 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FVE92_RS20750 Protein ID WP_002892066.1
Coordinates 3849171..3849545 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE92_RS20740 3844323..3845516 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FVE92_RS20745 3845539..3848685 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
FVE92_RS20750 3849171..3849545 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FVE92_RS20755 3849572..3849790 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FVE92_RS20760 3849949..3850515 + 567 WP_002892030.1 maltose O-acetyltransferase -
FVE92_RS20765 3850487..3850627 - 141 WP_004147370.1 hypothetical protein -
FVE92_RS20770 3850648..3851118 + 471 WP_002892026.1 YlaC family protein -
FVE92_RS20775 3851093..3852544 - 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
FVE92_RS20780 3852645..3853343 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
FVE92_RS20785 3853340..3853480 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FVE92_RS20790 3853480..3853743 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T136825 WP_002892050.1 NZ_CP042977:3849572-3849790 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T136825 NZ_CP042977:3849572-3849790 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT136825 WP_002892066.1 NZ_CP042977:3849171-3849545 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT136825 NZ_CP056245:c4363576-4363334 [Citrobacter freundii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCATTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References