Detailed information of TA system TA136811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 250275..250912
• Replicon: plasmid pK55602_1
• Accession: NZ_CP042975
• Organism: Klebsiella pneumoniae strain KPN55602

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: FVE92_RS01360
• Protein ID: WP_087638532.1
• Coordinates: 250275..250685 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: FVE92_RS01365
• Protein ID: WP_044265857.1
• Coordinates: 250682..250912 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE92_RS01335	245702..247009	-	1308	WP_044265869.1	amino acid permease	-
FVE92_RS01340	247218..247679	+	462	WP_044265866.1	Lrp/AsnC family transcriptional regulator	-
FVE92_RS01345	248055..248180	+	126	Protein_270	IS5/IS1182 family transposase	-
FVE92_RS01350	248187..248888	-	702	WP_044265986.1	aspartate/glutamate racemase family protein	-
FVE92_RS01355	249136..250116	-	981	WP_044265863.1	hypothetical protein	-
FVE92_RS01360	250275..250685	-	411	WP_087638532.1	PIN domain-containing protein	Toxin
FVE92_RS01365	250682..250912	-	231	WP_044265857.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FVE92_RS01370	251300..253438	+	2139	WP_044265854.1	AAA family ATPase	-
FVE92_RS01375	253718..254599	-	882	WP_044265851.1	hypothetical protein	-
FVE92_RS01380	254592..255200	-	609	WP_044265848.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	rmpA / rmpA / iroN / iroD / iroC / iroB	1..270776	270776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-127)

Antitoxin

• SpoVT-AbrB domain (7-47)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14426.37 Da
• Isoelectric Point: 4.4964

>T136811 WP_087638532.1 NZ_CP042975:c250685-250275 [Klebsiella pneumoniae]
VNRTYMLDTRFCAFILREQPEAVLGWLEQAVLRGHRIVISAITWAELSQAAREDSPATQALADAFCASLDVVLPWDRAAV
DATTEIKAALAATGTPLGPNDTAIAGHAIAAGAVLVTRNGGEFERVPGLTLQDWAG

Nucleotide

• Length: 411 bp

>T136811 NZ_CP042975:c250685-250275 [Klebsiella pneumoniae]
GTGAACAGAACGTATATGCTCGATACCCGTTTCTGCGCGTTCATCCTGCGCGAGCAGCCGGAAGCCGTGCTCGGGTGGCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATTGTGATTTCAGCCATCACATGGGCCGAGCTGTCACAGGCCGCGCGGGAGG
ACAGTCCCGCCACGCAGGCTCTGGCCGATGCGTTCTGCGCCAGTCTCGATGTCGTGCTGCCCTGGGACCGCGCCGCGGTG
GATGCGACCACGGAAATTAAGGCAGCCCTGGCGGCGACCGGGACGCCGCTGGGTCCTAACGACACGGCCATTGCCGGACA
CGCCATTGCCGCCGGTGCCGTGCTGGTGACGAGGAACGGGGGAGAGTTTGAGCGGGTGCCGGGCCTCACACTGCAAGACT
GGGCCGGTTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8575.81 Da
• Isoelectric Point: 5.0957

>AT136811 WP_044265857.1 NZ_CP042975:c250912-250682 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDCIILRPVRPAWNSFALMGKAGPEFMAEREVVISDNGRGEQ

Nucleotide

• Length: 231 bp

>AT136811 NZ_CP042975:c250912-250682 [Klebsiella pneumoniae]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACTGCATCATCCTGCGTCCCGTCCGCCCGGCCTGGAACTCATTCGCCCTGATGG
GGAAGGCCGGGCCTGAGTTTATGGCGGAGCGTGAAGTTGTTATAAGTGATAACGGGCGGGGTGAACAGTGA