Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 250275..250912 Replicon plasmid pK55602_1
Accession NZ_CP042975
Organism Klebsiella pneumoniae strain KPN55602

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag FVE92_RS01360 Protein ID WP_087638532.1
Coordinates 250275..250685 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag FVE92_RS01365 Protein ID WP_044265857.1
Coordinates 250682..250912 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE92_RS01335 245702..247009 - 1308 WP_044265869.1 amino acid permease -
FVE92_RS01340 247218..247679 + 462 WP_044265866.1 Lrp/AsnC family transcriptional regulator -
FVE92_RS01345 248055..248180 + 126 Protein_270 IS5/IS1182 family transposase -
FVE92_RS01350 248187..248888 - 702 WP_044265986.1 aspartate/glutamate racemase family protein -
FVE92_RS01355 249136..250116 - 981 WP_044265863.1 hypothetical protein -
FVE92_RS01360 250275..250685 - 411 WP_087638532.1 PIN domain-containing protein Toxin
FVE92_RS01365 250682..250912 - 231 WP_044265857.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FVE92_RS01370 251300..253438 + 2139 WP_044265854.1 AAA family ATPase -
FVE92_RS01375 253718..254599 - 882 WP_044265851.1 hypothetical protein -
FVE92_RS01380 254592..255200 - 609 WP_044265848.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - rmpA / rmpA / iroN / iroD / iroC / iroB 1..270776 270776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14426.37 Da        Isoelectric Point: 4.4964

>T136811 WP_087638532.1 NZ_CP042975:c250685-250275 [Klebsiella pneumoniae]
VNRTYMLDTRFCAFILREQPEAVLGWLEQAVLRGHRIVISAITWAELSQAAREDSPATQALADAFCASLDVVLPWDRAAV
DATTEIKAALAATGTPLGPNDTAIAGHAIAAGAVLVTRNGGEFERVPGLTLQDWAG

Download         Length: 411 bp

>T136811 NZ_CP042975:c250685-250275 [Klebsiella pneumoniae]
GTGAACAGAACGTATATGCTCGATACCCGTTTCTGCGCGTTCATCCTGCGCGAGCAGCCGGAAGCCGTGCTCGGGTGGCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATTGTGATTTCAGCCATCACATGGGCCGAGCTGTCACAGGCCGCGCGGGAGG
ACAGTCCCGCCACGCAGGCTCTGGCCGATGCGTTCTGCGCCAGTCTCGATGTCGTGCTGCCCTGGGACCGCGCCGCGGTG
GATGCGACCACGGAAATTAAGGCAGCCCTGGCGGCGACCGGGACGCCGCTGGGTCCTAACGACACGGCCATTGCCGGACA
CGCCATTGCCGCCGGTGCCGTGCTGGTGACGAGGAACGGGGGAGAGTTTGAGCGGGTGCCGGGCCTCACACTGCAAGACT
GGGCCGGTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8575.81 Da        Isoelectric Point: 5.0957

>AT136811 WP_044265857.1 NZ_CP042975:c250912-250682 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDCIILRPVRPAWNSFALMGKAGPEFMAEREVVISDNGRGEQ

Download         Length: 231 bp

>AT136811 NZ_CP042975:c250912-250682 [Klebsiella pneumoniae]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACTGCATCATCCTGCGTCCCGTCCGCCCGGCCTGGAACTCATTCGCCCTGATGG
GGAAGGCCGGGCCTGAGTTTATGGCGGAGCGTGAAGTTGTTATAAGTGATAACGGGCGGGGTGAACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References