Detailed information of TA system TA136810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 189601..190123
• Replicon: plasmid pK55602_1
• Accession: NZ_CP042975
• Organism: Klebsiella pneumoniae strain KPN55602

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: FVE92_RS01045
• Protein ID: WP_044265921.1
• Coordinates: 189839..190123 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: A0A2J4ZSR4
• Locus tag: FVE92_RS01040
• Protein ID: WP_004187025.1
• Coordinates: 189601..189849 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE92_RS01005	184828..185649	+	822	WP_044265935.1	helix-turn-helix transcriptional regulator	-
FVE92_RS01010	185678..185890	-	213	Protein_203	DUF3363 domain-containing protein	-
FVE92_RS01015	185893..186261	-	369	Protein_204	DUF4102 domain-containing protein	-
FVE92_RS01020	186670..187008	-	339	WP_044265932.1	carboxymuconolactone decarboxylase family protein	-
FVE92_RS01025	187026..187595	-	570	WP_044265930.1	TetR/AcrR family transcriptional regulator	-
FVE92_RS01030	187782..188339	-	558	WP_044265927.1	OsmC family protein	-
FVE92_RS01035	188725..189192	+	468	WP_044265924.1	GNAT family N-acetyltransferase	-
FVE92_RS01040	189601..189849	+	249	WP_004187025.1	plasmid stabilization protein	Antitoxin
FVE92_RS01045	189839..190123	+	285	WP_044265921.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FVE92_RS01050	190139..191413	-	1275	WP_044265918.1	ISNCY family transposase	-
FVE92_RS01055	191586..192551	+	966	WP_044265916.1	hypothetical protein	-
FVE92_RS01060	192673..193176	-	504	WP_044265998.1	DinB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	rmpA / rmpA / iroN / iroD / iroC / iroB	1..270776	270776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11012.73 Da
• Isoelectric Point: 10.5388

>T136810 WP_044265921.1 NZ_CP042975:189839-190123 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVHFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Nucleotide

• Length: 285 bp

>T136810 NZ_CP042975:189839-190123 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTGCAGGTGCATTTCAA
AAAGAAGCTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATACCGCCTTGTCTATCGTGTAGAGGACGACATTGTTACCGTCACTGTTATCGGTGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9011.24 Da
• Isoelectric Point: 3.9947

>AT136810 WP_004187025.1 NZ_CP042975:189601-189849 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT136810 NZ_CP042975:189601-189849 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACGGCAGCCAGCATTACTGAGCTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTGAATCGTAATGAGCCTGCATTCTACTGCGTGCCACCGGCACTGTATGCCCAGTTGA
TGGAACTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A2J4ZSR4