Detailed information of TA system TA136808

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 107173..108089
• Replicon: plasmid pK55602_1
• Accession: NZ_CP042975
• Organism: Klebsiella pneumoniae strain KPN55602

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FVE92_RS00580
• Protein ID: WP_114444169.1
• Coordinates: 107613..108089 (+)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A6P1V3Q9
• Locus tag: FVE92_RS00575
• Protein ID: WP_004026357.1
• Coordinates: 107173..107616 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE92_RS00545	102191..102712	+	522	WP_004213635.1	sigma-70 family RNA polymerase sigma factor	-
FVE92_RS00550	102709..103662	+	954	Protein_111	fec operon regulator FecR	-
FVE92_RS00555	103749..105875	+	2127	WP_004213640.1	TonB-dependent receptor family protein	-
FVE92_RS00560	105950..106105	+	156	WP_004213642.1	hypothetical protein	-
FVE92_RS00565	106250..106471	+	222	WP_004213643.1	DUF2188 domain-containing protein	-
FVE92_RS00570	106569..107072	+	504	Protein_115	DUF4113 domain-containing protein	-
FVE92_RS00575	107173..107616	+	444	WP_004026357.1	DUF2384 domain-containing protein	Antitoxin
FVE92_RS00580	107613..108089	+	477	WP_114444169.1	RES family NAD+ phosphorylase	Toxin
FVE92_RS00585	108032..108211	-	180	Protein_118	IS3 family transposase	-
FVE92_RS00590	108266..108963	+	698	Protein_119	IS1 family transposase	-
FVE92_RS00595	110348..111297	-	950	Protein_120	DUF1173 family protein	-
FVE92_RS00600	111475..111969	+	495	WP_004212794.1	thermonuclease family protein	-
FVE92_RS00605	112306..112704	+	399	WP_004212796.1	H-NS histone family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	rmpA / rmpA / iroN / iroD / iroC / iroB	1..270776	270776
	-	flank	IS/Tn	-	-	108460..108963	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-138)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 17743.18 Da
• Isoelectric Point: 4.7156

>T136808 WP_114444169.1 NZ_CP042975:107613-108089 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIVWVHHILQFLLSRKI

Nucleotide

• Length: 477 bp

>T136808 NZ_CP042975:107613-108089 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATTGTATGGGTCCACCACATATTGCAATTTTTACTCTCACGTAAAATATAG

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16480.80 Da
• Isoelectric Point: 10.2498

>AT136808 WP_004026357.1 NZ_CP042975:107173-107616 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT136808 NZ_CP042975:107173-107616 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A6P1V3Q9