Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3633945..3634563 Replicon chromosome
Accession NZ_CP042973
Organism Escherichia coli strain CFSAN061768

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CA694_RS17420 Protein ID WP_001291435.1
Coordinates 3634345..3634563 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag CA694_RS17415 Protein ID WP_000344800.1
Coordinates 3633945..3634319 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA694_RS17405 (3629034) 3629034..3630227 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CA694_RS17410 (3630250) 3630250..3633399 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
CA694_RS17415 (3633945) 3633945..3634319 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
CA694_RS17420 (3634345) 3634345..3634563 + 219 WP_001291435.1 HHA domain-containing protein Toxin
CA694_RS17425 (3634735) 3634735..3635286 + 552 WP_000102564.1 maltose O-acetyltransferase -
CA694_RS17430 (3635402) 3635402..3635872 + 471 WP_000136192.1 YlaC family protein -
CA694_RS17435 (3636030) 3636030..3636188 + 159 Protein_3426 EAL domain-containing protein -
CA694_RS17440 (3636243) 3636243..3636940 + 698 WP_225893468.1 IS1 family transposase -
CA694_RS17445 (3636956) 3636956..3638362 + 1407 Protein_3428 cyclic-guanylate-specific phosphodiesterase PdeB -
CA694_RS17450 (3638404) 3638404..3638757 - 354 WP_001550741.1 DUF1428 family protein -
CA694_RS17460 (3639136) 3639136..3639447 + 312 WP_000409911.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T136800 WP_001291435.1 NZ_CP042973:3634345-3634563 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T136800 NZ_CP042973:3634345-3634563 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT136800 WP_000344800.1 NZ_CP042973:3633945-3634319 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT136800 NZ_CP056238:c4394768-4394526 [Citrobacter freundii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References