Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1944623..1945455 | Replicon | chromosome |
| Accession | NZ_CP042973 | ||
| Organism | Escherichia coli strain CFSAN061768 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1L4HFA4 |
| Locus tag | CA694_RS09285 | Protein ID | WP_032163901.1 |
| Coordinates | 1944623..1944997 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | CA694_RS09290 | Protein ID | WP_001295723.1 |
| Coordinates | 1945087..1945455 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CA694_RS09245 (1940019) | 1940019..1941185 | + | 1167 | WP_042031746.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| CA694_RS09250 (1941304) | 1941304..1941777 | + | 474 | WP_001105415.1 | DNA gyrase inhibitor SbmC | - |
| CA694_RS09255 (1941975) | 1941975..1943033 | + | 1059 | WP_001200891.1 | FUSC family protein | - |
| CA694_RS09260 (1943205) | 1943205..1943534 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| CA694_RS09265 (1943635) | 1943635..1943769 | - | 135 | WP_001297944.1 | EutP/PduV family microcompartment system protein | - |
| CA694_RS09270 (1943889) | 1943889..1944017 | + | 129 | Protein_1821 | transposase domain-containing protein | - |
| CA694_RS09275 (1944306) | 1944306..1944386 | - | 81 | Protein_1822 | hypothetical protein | - |
| CA694_RS09280 (1944432) | 1944432..1944626 | - | 195 | WP_000988600.1 | DUF5983 family protein | - |
| CA694_RS09285 (1944623) | 1944623..1944997 | - | 375 | WP_032163901.1 | TA system toxin CbtA family protein | Toxin |
| CA694_RS09290 (1945087) | 1945087..1945455 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CA694_RS09295 (1945618) | 1945618..1945839 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| CA694_RS09300 (1945902) | 1945902..1946378 | - | 477 | WP_001186726.1 | RadC family protein | - |
| CA694_RS09305 (1946394) | 1946394..1946879 | - | 486 | WP_000849582.1 | antirestriction protein | - |
| CA694_RS09310 (1946934) | 1946934..1947752 | - | 819 | WP_040061766.1 | DUF932 domain-containing protein | - |
| CA694_RS09315 (1947852) | 1947852..1948085 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| CA694_RS09320 (1948164) | 1948164..1948619 | - | 456 | WP_000581504.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13919.89 Da Isoelectric Point: 7.7760
>T136787 WP_032163901.1 NZ_CP042973:c1944997-1944623 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T136787 NZ_CP042973:c1944997-1944623 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT136787 WP_001295723.1 NZ_CP042973:c1945455-1945087 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT136787 NZ_CP042973:c1945455-1945087 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1L4HFA4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |