Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 826911..827743 Replicon chromosome
Accession NZ_CP042973
Organism Escherichia coli strain CFSAN061768

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag CA694_RS03930 Protein ID WP_001094454.1
Coordinates 826911..827285 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag CA694_RS03935 Protein ID WP_001320394.1
Coordinates 827375..827743 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA694_RS03900 (822025) 822025..823173 - 1149 WP_000905931.1 capsule polysaccharide export inner-membrane protein KpsE -
CA694_RS03905 (823245) 823245..824228 - 984 WP_024181915.1 KpsF/GutQ family sugar-phosphate isomerase -
CA694_RS03910 (825038) 825038..825208 - 171 Protein_770 IS110 family transposase -
CA694_RS03915 (825551) 825551..826120 - 570 WP_001290250.1 DUF4942 domain-containing protein -
CA694_RS03920 (826217) 826217..826414 - 198 WP_000839276.1 DUF957 domain-containing protein -
CA694_RS03925 (826426) 826426..826914 - 489 WP_000777545.1 DUF5983 family protein -
CA694_RS03930 (826911) 826911..827285 - 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
CA694_RS03935 (827375) 827375..827743 - 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CA694_RS03940 (827793) 827793..828436 - 644 Protein_776 antitoxin of toxin-antitoxin stability system -
CA694_RS03945 (828455) 828455..828676 - 222 WP_000692300.1 DUF987 domain-containing protein -
CA694_RS03950 (828739) 828739..829215 - 477 WP_001347688.1 RadC family protein -
CA694_RS03955 (829231) 829231..829716 - 486 WP_029701480.1 antirestriction protein -
CA694_RS03960 (829771) 829771..830589 - 819 WP_001234642.1 DUF932 domain-containing protein -
CA694_RS03965 (830689) 830689..830922 - 234 WP_001119719.1 DUF905 family protein -
CA694_RS03970 (831001) 831001..831456 - 456 WP_000581493.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T136782 WP_001094454.1 NZ_CP042973:c827285-826911 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T136782 NZ_CP056232:2603305-2603787 [Citrobacter freundii]
GTGGGATTTGTAACTGCACCTGAACCACTAACTCACATTCATCAATTGGCGGAATTTGTCAGCGGAGAAATTGTTCTCGA
TGATTGGTTAAAGCAAAAAGGGCTAAAAAATCAGGCTCTCGGCGCAGCCAGGACGTTTGTTGTCTGCAAAACAGACACGC
GACAAGTCGCTGGCTTTTATTCACTGGCCACTGGTAGCGTCAACCACACAGAAGCAACAGGCAATCTTCGCCGTAGCATG
CCAGATCCAATCCCCGTAATTATCCTTGCCAGATTGGCCGTAGATCTTTCTGTTCGTGGAAAAGGATTAGGGGCCGATCT
GCTTCACGATGCAGTACTGCGGTGTTACAAAGTGGCAGAGAATATTGGCGTGCGTGCCGTTATGGTGCATGCGCTCACAG
ACGAAGCTAAACGTTTTTATCTTCACCACGGATTCAAAGCATCTCAACTGCAGGAGCGAACTCTGTTCCTTAGGCTTTCA
TGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT136782 WP_001320394.1 NZ_CP042973:c827743-827375 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT136782 NZ_CP042973:c827743-827375 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References