Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4591817..4592742 Replicon chromosome
Accession NZ_CP042969
Organism Escherichia coli strain CFSAN061769

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag CA697_RS22190 Protein ID WP_014640052.1
Coordinates 4591817..4592203 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag CA697_RS22195 Protein ID WP_001339382.1
Coordinates 4592233..4592742 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA697_RS22140 (4587142) 4587142..4587504 + 363 WP_000135691.1 protein YfdP -
CA697_RS22145 (4587570) 4587570..4588394 + 825 WP_116326947.1 DUF2303 family protein -
CA697_RS22150 (4588522) 4588522..4589057 + 536 Protein_4349 5'-deoxynucleotidase -
CA697_RS22155 (4589048) 4589048..4589926 + 879 WP_053287588.1 phosphoadenosine phosphosulfate reductase family protein -
CA697_RS22160 (4589923) 4589923..4590126 + 204 WP_000156999.1 hypothetical protein -
CA697_RS22165 (4590119) 4590119..4590358 + 240 WP_000476212.1 hypothetical protein -
CA697_RS22170 (4590355) 4590355..4590666 + 312 WP_000073886.1 hypothetical protein -
CA697_RS22175 (4590666) 4590666..4591238 + 573 WP_063501529.1 3'-5' exonuclease -
CA697_RS22180 (4591275) 4591275..4591556 + 282 WP_001093918.1 pyocin activator PrtN family protein -
CA697_RS22185 (4591604) 4591604..4591777 - 174 WP_000390072.1 hypothetical protein -
CA697_RS22190 (4591817) 4591817..4592203 - 387 WP_014640052.1 hypothetical protein Toxin
CA697_RS22195 (4592233) 4592233..4592742 - 510 WP_001339382.1 Panacea domain-containing protein Antitoxin
CA697_RS22200 (4593059) 4593059..4593163 - 105 Protein_4359 tRNA-dihydrouridine synthase -
CA697_RS22205 (4593526) 4593526..4594542 - 1017 WP_000912595.1 DUF2713 family protein -
CA697_RS22210 (4594860) 4594860..4595375 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
CA697_RS22215 (4595417) 4595417..4595626 - 210 WP_001030593.1 CsbD family protein -
CA697_RS22220 (4595742) 4595742..4597067 - 1326 WP_001301116.1 MATE family efflux transporter DinF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4550312..4597748 47436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T136770 WP_014640052.1 NZ_CP042969:c4592203-4591817 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T136770 NZ_CP042969:c4592203-4591817 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19576.29 Da        Isoelectric Point: 5.3338

>AT136770 WP_001339382.1 NZ_CP042969:c4592742-4592233 [Escherichia coli]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT136770 NZ_CP056229:2401676-2401972 [Citrobacter freundii]
ATGGAGAAACTTATGCAAACCAGCGCTCGTAAGCCAACTCGCGATAAGCAAATTAATATCCGCGCTACTGATGAGGAACG
CGCAGTGATTGATTATGCCGCAAGTTTGGTTAATAAAAACCGCACTGACTTTATCATTGAGAAGGCCGTGCATGAGGCCC
AGAATATCATTCTGGATCAGCGTGTGTTCGTCCTAGACGATGCCCGATATCAGTCTTTCATTGAGCAGCTTGAAGCGCCT
GTACAAAATGTTGAGGGGCGTCAACGCCTGATGGATGTGAAGCCAGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References