Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4458915..4459750 | Replicon | chromosome |
| Accession | NZ_CP042969 | ||
| Organism | Escherichia coli strain CFSAN061769 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | CA697_RS21470 | Protein ID | WP_057109034.1 |
| Coordinates | 4459373..4459750 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1E5MC43 |
| Locus tag | CA697_RS21465 | Protein ID | WP_063112944.1 |
| Coordinates | 4458915..4459283 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CA697_RS21425 (4454108) | 4454108..4454992 | + | 885 | WP_032216515.1 | 50S ribosome-binding GTPase | - |
| CA697_RS21430 (4455111) | 4455111..4455788 | + | 678 | WP_063091580.1 | hypothetical protein | - |
| CA697_RS21435 (4455794) | 4455794..4455946 | + | 153 | WP_001696589.1 | DUF905 family protein | - |
| CA697_RS21440 (4456047) | 4456047..4456865 | + | 819 | WP_001234688.1 | DUF932 domain-containing protein | - |
| CA697_RS21445 (4456947) | 4456947..4457426 | + | 480 | WP_000860074.1 | antirestriction protein | - |
| CA697_RS21450 (4457442) | 4457442..4457918 | + | 477 | WP_001366830.1 | RadC family protein | - |
| CA697_RS21455 (4457981) | 4457981..4458202 | + | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| CA697_RS21460 (4458221) | 4458221..4458865 | + | 645 | WP_045146861.1 | hypothetical protein | - |
| CA697_RS21465 (4458915) | 4458915..4459283 | + | 369 | WP_063112944.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CA697_RS21470 (4459373) | 4459373..4459750 | + | 378 | WP_057109034.1 | TA system toxin CbtA family protein | Toxin |
| CA697_RS21475 (4459747) | 4459747..4459896 | + | 150 | Protein_4212 | DUF5983 family protein | - |
| CA697_RS21480 (4459972) | 4459972..4460169 | + | 198 | WP_023563519.1 | DUF957 domain-containing protein | - |
| CA697_RS21485 (4460254) | 4460254..4461096 | + | 843 | WP_001529559.1 | DUF4942 domain-containing protein | - |
| CA697_RS21490 (4461845) | 4461845..4463383 | + | 1539 | WP_001187171.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4400527..4471196 | 70669 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13934.86 Da Isoelectric Point: 6.8517
>T136768 WP_057109034.1 NZ_CP042969:4459373-4459750 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ
Download Length: 378 bp
>T136768 NZ_CP042969:4459373-4459750 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13724.52 Da Isoelectric Point: 6.8270
>AT136768 WP_063112944.1 NZ_CP042969:4458915-4459283 [Escherichia coli]
VSDTLPGTTHHDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLPGTTHHDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT136768 NZ_CP042969:4458915-4459283 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCACGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCATCACGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|