Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4285525..4286120 Replicon chromosome
Accession NZ_CP042969
Organism Escherichia coli strain CFSAN061769

Toxin (Protein)


Gene name chpB Uniprot ID A0A3L3YDL1
Locus tag CA697_RS20590 Protein ID WP_000239576.1
Coordinates 4285525..4285875 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag CA697_RS20595 Protein ID WP_001223208.1
Coordinates 4285869..4286120 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA697_RS20570 (4280801) 4280801..4281823 - 1023 WP_001296689.1 ABC transporter permease -
CA697_RS20575 (4281837) 4281837..4283339 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
CA697_RS20580 (4283649) 4283649..4284605 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
CA697_RS20585 (4284915) 4284915..4285445 + 531 WP_000055075.1 inorganic diphosphatase -
CA697_RS20590 (4285525) 4285525..4285875 - 351 WP_000239576.1 endoribonuclease toxin ChpB Toxin
CA697_RS20595 (4285869) 4285869..4286120 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
CA697_RS20600 (4286332) 4286332..4286673 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
CA697_RS20605 (4286676) 4286676..4290455 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12566.53 Da        Isoelectric Point: 6.2232

>T136767 WP_000239576.1 NZ_CP042969:c4285875-4285525 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T136767 NZ_CP042969:c4285875-4285525 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTAGGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT136767 WP_001223208.1 NZ_CP042969:c4286120-4285869 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT136767 NZ_CP056229:800272-800538 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTGGACATTTCGATCATGCCGTT
TTTCGAACATGAGTATGACAACTTAAGTGATGACGAAAAGCGCATTTTTATCCGTTTGCTGGAATGTGATGACCCCGATT
TATTTAACTGGTTGATGAATCACGGGAAGCCGGCTGATGCACAGCTGGAGCAAATGGTACGGCTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L3YDL1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References