Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2942008..2942848 | Replicon | chromosome |
| Accession | NZ_CP042969 | ||
| Organism | Escherichia coli strain CFSAN061769 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B1LJY4 |
| Locus tag | CA697_RS14365 | Protein ID | WP_000854686.1 |
| Coordinates | 2942008..2942391 (-) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1M0YJ34 |
| Locus tag | CA697_RS14370 | Protein ID | WP_001360163.1 |
| Coordinates | 2942468..2942848 (-) | Length | 127 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CA697_RS14325 (2937010) | 2937010..2937501 | - | 492 | WP_063082244.1 | DUF1097 domain-containing protein | - |
| CA697_RS14330 (2937603) | 2937603..2938157 | - | 555 | WP_001001902.1 | molecular chaperone YcdY | - |
| CA697_RS14335 (2938181) | 2938181..2938918 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| CA697_RS14340 (2938973) | 2938973..2939911 | - | 939 | WP_032296764.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| CA697_RS14350 (2940382) | 2940382..2941224 | - | 843 | WP_001274547.1 | DUF4942 domain-containing protein | - |
| CA697_RS14355 (2941309) | 2941309..2941506 | - | 198 | WP_000839253.1 | DUF957 domain-containing protein | - |
| CA697_RS14360 (2941523) | 2941523..2942011 | - | 489 | WP_001054233.1 | DUF5983 family protein | - |
| CA697_RS14365 (2942008) | 2942008..2942391 | - | 384 | WP_000854686.1 | TA system toxin CbtA family protein | Toxin |
| CA697_RS14370 (2942468) | 2942468..2942848 | - | 381 | WP_001360163.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CA697_RS14375 (2942859) | 2942859..2943542 | - | 684 | WP_000086769.1 | hypothetical protein | - |
| CA697_RS14380 (2943561) | 2943561..2943782 | - | 222 | WP_000692298.1 | DUF987 domain-containing protein | - |
| CA697_RS14385 (2943845) | 2943845..2944321 | - | 477 | WP_001186726.1 | RadC family protein | - |
| CA697_RS14390 (2944337) | 2944337..2944822 | - | 486 | WP_000214307.1 | antirestriction protein | - |
| CA697_RS14395 (2944914) | 2944914..2945732 | - | 819 | WP_001234732.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14272.28 Da Isoelectric Point: 6.8614
>T136763 WP_000854686.1 NZ_CP042969:c2942391-2942008 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ
Download Length: 384 bp
>T136763 NZ_CP042969:c2942391-2942008 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA
Antitoxin
Download Length: 127 a.a. Molecular weight: 13950.74 Da Isoelectric Point: 5.0823
>AT136763 WP_001360163.1 NZ_CP042969:c2942848-2942468 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCIVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
VSDTLPGTTLPDDNKDRPWWGLPCIVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
Download Length: 381 bp
>AT136763 NZ_CP042969:c2942848-2942468 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCATCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCATCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|