Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2737806..2738397 Replicon chromosome
Accession NZ_CP042966
Organism Sulfurospirillum multivorans strain N

Toxin (Protein)


Gene name hicA Uniprot ID A0A5B9TV06
Locus tag SMN_RS14195 Protein ID WP_025345913.1
Coordinates 2737806..2738060 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5B9TVU5
Locus tag SMN_RS14200 Protein ID WP_025345914.1
Coordinates 2738053..2738397 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMN_RS14175 2733282..2733970 - 689 Protein_2804 response regulator transcription factor -
SMN_RS14180 2734092..2735720 - 1629 WP_025345910.1 methyl-accepting chemotaxis protein -
SMN_RS14185 2735924..2736148 + 225 WP_025345911.1 hypothetical protein -
SMN_RS14190 2736252..2737676 + 1425 WP_025345912.1 hypothetical protein -
SMN_RS14195 2737806..2738060 + 255 WP_025345913.1 type II toxin-antitoxin system HicA family toxin Toxin
SMN_RS14200 2738053..2738397 + 345 WP_025345914.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SMN_RS14205 2738458..2739759 - 1302 WP_025345915.1 DNA polymerase IV -
SMN_RS14210 2740088..2740660 + 573 WP_025345916.1 DedA family protein -
SMN_RS14215 2740657..2741007 - 351 WP_025345917.1 hypothetical protein -
SMN_RS14220 2741147..2743132 - 1986 WP_025345918.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(22-81)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9683.46 Da        Isoelectric Point: 10.3565

>T136739 WP_025345913.1 NZ_CP042966:2737806-2738060 [Sulfurospirillum multivorans]
MSKKDKLWAKFMEVPPKKNLTWNELSALMLALGFEALQGDGSRVKFYHKAKDIMINLHKPHPGNLLKTYLVKQIQDKLKE
AFDG

Download         Length: 255 bp

>T136739 NZ_CP042966:2737806-2738060 [Sulfurospirillum multivorans]
ATGAGTAAAAAAGATAAACTTTGGGCTAAATTTATGGAAGTCCCACCCAAAAAGAACTTAACTTGGAATGAACTCTCCGC
ATTGATGTTAGCGCTTGGTTTTGAAGCATTACAGGGTGATGGCTCACGAGTGAAGTTTTATCATAAAGCTAAAGACATAA
TGATCAATCTTCATAAACCCCATCCTGGCAATTTACTCAAAACGTATCTTGTAAAACAGATACAAGACAAACTAAAGGAG
GCATTTGATGGCTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12936.69 Da        Isoelectric Point: 4.6967

>AT136739 WP_025345914.1 NZ_CP042966:2738053-2738397 [Sulfurospirillum multivorans]
MANVLTYQNYTGSVEYSHEDRCFFGKIEFINDLITFEATSVDELETNFQEAVESYMLTCKELGKEPQKQFNGVFNIRPGV
ELHMAAARKAMEVGMSLNAYIKSLIAKDTHLSIN

Download         Length: 345 bp

>AT136739 NZ_CP042966:2738053-2738397 [Sulfurospirillum multivorans]
ATGGCTAATGTATTGACCTATCAAAACTATACTGGCTCAGTAGAATACAGTCATGAAGACCGATGTTTCTTTGGAAAAAT
CGAATTTATTAATGACTTGATCACCTTTGAAGCGACGAGTGTTGATGAGCTCGAAACCAATTTTCAAGAAGCGGTTGAGA
GTTATATGCTTACATGTAAAGAGCTAGGCAAAGAGCCACAAAAGCAATTTAACGGCGTGTTCAACATTCGCCCAGGCGTT
GAACTGCATATGGCGGCTGCGCGTAAAGCGATGGAAGTGGGGATGTCTTTGAACGCTTATATCAAAAGTCTTATCGCTAA
AGATACCCATCTTTCTATCAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B9TV06

Antitoxin

Source ID Structure
AlphaFold DB A0A5B9TVU5

References