Detailed information of TA system TA136738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 1286737..1287374
• Replicon: chromosome
• Accession: NZ_CP042966
• Organism: Sulfurospirillum multivorans strain N

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SMN_RS06620
• Protein ID: WP_025344463.1
• Coordinates: 1286973..1287374 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5B9TR85
• Locus tag: SMN_RS06615
• Protein ID: WP_025344462.1
• Coordinates: 1286737..1286976 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMN_RS06595	1282461..1283585	-	1125	WP_025344458.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
SMN_RS06600	1283600..1284637	+	1038	WP_148295274.1	HlyD family efflux transporter periplasmic adaptor subunit	-
SMN_RS06605	1284634..1285572	+	939	WP_025344460.1	ABC transporter ATP-binding protein	-
SMN_RS06610	1285569..1286672	+	1104	WP_025344461.1	ABC transporter permease	-
SMN_RS06615	1286737..1286976	+	240	WP_025344462.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SMN_RS06620	1286973..1287374	+	402	WP_025344463.1	type II toxin-antitoxin system VapC family toxin	Toxin
SMN_RS06625	1287477..1288508	+	1032	WP_025344464.1	hypothetical protein	-
SMN_RS06630	1288517..1289239	-	723	WP_158506022.1	hypothetical protein	-
SMN_RS16535	1289248..1289394	-	147	WP_169730520.1	hypothetical protein	-
SMN_RS06635	1289559..1289819	-	261	WP_025344466.1	helix-turn-helix domain-containing protein	-
SMN_RS06640	1289966..1291099	+	1134	WP_025344467.1	aldo/keto reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (8-52)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15116.71 Da
• Isoelectric Point: 7.2419

>T136738 WP_025344463.1 NZ_CP042966:1286973-1287374 [Sulfurospirillum multivorans]
MKKMLDTNICIYIIKNKPQSVLDELKKCNVGDIILSSITVSELIYGAHKSQFVEKNLKAIEHFLIPFDVAEYDYKAALEY
GKLRASLEKKGQPIGSLDMLIAAHAKSLDMVLVTNNMKEFERVEGLNVENWVR

Nucleotide

• Length: 402 bp

>T136738 NZ_CP056216:730653-731138 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9377.66 Da
• Isoelectric Point: 7.0128

>AT136738 WP_025344462.1 NZ_CP042966:1286737-1286976 [Sulfurospirillum multivorans]
MTSTAKLFQNGQSQAIRLPKEYRFEHQQEVIIKKIDGAILIFPKNDKSVWEKMFDTLGNFSDDFLAQRRQPTQEREELF

Nucleotide

• Length: 240 bp

>AT136738 NZ_CP042966:1286737-1286976 [Sulfurospirillum multivorans]
ATGACTTCTACAGCAAAACTATTTCAAAATGGTCAAAGTCAAGCTATACGCCTTCCCAAGGAGTATCGGTTTGAACATCA
ACAAGAGGTTATCATCAAAAAAATAGATGGTGCCATTTTGATATTCCCTAAAAACGATAAAAGTGTTTGGGAAAAAATGT
TCGATACTCTGGGTAACTTTTCAGATGACTTTCTAGCGCAAAGAAGACAACCAACACAAGAGCGAGAGGAGCTGTTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A5B9TR85