Detailed information of TA system TA136737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 1166305..1166942
• Replicon: chromosome
• Accession: NZ_CP042966
• Organism: Sulfurospirillum multivorans strain N

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SMN_RS05975
• Protein ID: WP_025344340.1
• Coordinates: 1166541..1166942 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5B9TQW3
• Locus tag: SMN_RS05970
• Protein ID: WP_025344339.1
• Coordinates: 1166305..1166544 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMN_RS05950	1161938..1163515	-	1578	WP_025344335.1	cbb3-type cytochrome c oxidase subunit I	-
SMN_RS05955	1163499..1164122	-	624	WP_025344336.1	ABC transporter ATP-binding protein	-
SMN_RS05960	1164122..1165204	-	1083	WP_025344337.1	FtsX-like permease family protein	-
SMN_RS05965	1165342..1166226	+	885	WP_025344338.1	3'-5' exonuclease	-
SMN_RS05970	1166305..1166544	+	240	WP_025344339.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SMN_RS05975	1166541..1166942	+	402	WP_025344340.1	type II toxin-antitoxin system VapC family toxin	Toxin
SMN_RS05980	1167035..1167397	+	363	WP_025344341.1	hypothetical protein	-
SMN_RS05985	1167470..1168816	+	1347	WP_084613089.1	AAA family ATPase	-
SMN_RS05990	1168813..1169583	+	771	WP_025344343.1	TIGR02646 family protein	-
SMN_RS05995	1169628..1170830	-	1203	WP_025343245.1	IS256 family transposase	-
SMN_RS06000	1170907..1171347	-	441	WP_025344345.1	isoprenylcysteine carboxylmethyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1169628..1170830	1202

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (8-54)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15068.58 Da
• Isoelectric Point: 6.7146

>T136737 WP_025344340.1 NZ_CP042966:1166541-1166942 [Sulfurospirillum multivorans]
MKKMLDTNICIYIIKNKPPSVLEELKKCDVGDIILSSITVSELIYGAHKSQFVEKTLKAIEHFLIPFDVADYDYKASLEY
GKIRANLEQKGQPIGSLDTLIAAHAKSLDVVLVTNNMKEFERVEGLKVENWVR

Nucleotide

• Length: 402 bp

>T136737 NZ_CP056216:351726-352073 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9318.64 Da
• Isoelectric Point: 5.8317

>AT136737 WP_025344339.1 NZ_CP042966:1166305-1166544 [Sulfurospirillum multivorans]
MTSTAKLFQNGQSQAIRLPKEFRFEHQQEVIIKKIDGAILIFPKNDKSVWEKMFETLGNFSDDFLAQRVQPTQEREELF

Nucleotide

• Length: 240 bp

>AT136737 NZ_CP056216:352073-352372 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATGGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A5B9TQW3