Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 613190..613695 Replicon chromosome
Accession NZ_CP042966
Organism Sulfurospirillum multivorans strain N

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1D7THD5
Locus tag SMN_RS03205 Protein ID WP_025343819.1
Coordinates 613435..613695 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1D7THA9
Locus tag SMN_RS03200 Protein ID WP_025343818.1
Coordinates 613190..613438 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMN_RS03155 608952..609245 + 294 WP_025343809.1 nucleotidyltransferase -
SMN_RS03160 609238..609591 + 354 WP_025343810.1 DUF86 domain-containing protein -
SMN_RS03165 609734..611062 + 1329 WP_025343811.1 OprD family outer membrane porin -
SMN_RS03170 611225..611506 + 282 WP_025343812.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SMN_RS03175 611493..611816 + 324 WP_025343813.1 type II toxin-antitoxin system RelE/ParE family toxin -
SMN_RS03180 611929..612183 + 255 WP_084613067.1 DUF4258 domain-containing protein -
SMN_RS03185 612173..612370 + 198 WP_025343815.1 DUF2283 domain-containing protein -
SMN_RS03190 612606..612821 + 216 WP_025343816.1 CopG family transcriptional regulator -
SMN_RS03195 612811..613065 + 255 WP_025343817.1 type II toxin-antitoxin system RelE/ParE family toxin -
SMN_RS03200 613190..613438 + 249 WP_025343818.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SMN_RS03205 613435..613695 + 261 WP_025343819.1 Txe/YoeB family addiction module toxin Toxin
SMN_RS03210 613821..615107 + 1287 WP_025343820.1 OprD family outer membrane porin -
SMN_RS03215 615266..615556 + 291 WP_025343821.1 nucleotidyltransferase domain-containing protein -
SMN_RS03220 615774..616028 + 255 WP_145923217.1 hypothetical protein -
SMN_RS03225 616324..617442 + 1119 WP_025343823.1 ABC transporter substrate-binding protein -
SMN_RS03230 617555..618439 + 885 WP_038533775.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10353.99 Da        Isoelectric Point: 9.3793

>T136735 WP_025343819.1 NZ_CP042966:613435-613695 [Sulfurospirillum multivorans]
MIIGFAAKGWEDYLYWQENDKKIVKRINLLLEDIKRNPHDSNGIGKPERLKGDLEKYFSRRITAEHRLVYKFLDDLIIVA
QCRFHY

Download         Length: 261 bp

>T136735 NZ_CP056201:c224810-224352 [Citrobacter sp. RHBSTW-00986]
GTGATCCTTTACCGACTGACCAAGACCCGTTATCTGATGACTGCGTGGTCTGGTCTGGGTGCGAAAGAAACGGGGGGCCG
CTGGAACAGCGTAGGCACTGCAATGGTCTACCTGTCTGAAACGGCCAGCCTTACCATGCTTGAAACGCTGGTACACATTC
ACGCGCCGCAGTTACTGGACGACTTTACACTGCTGAGTCTTGATGTACCGGATGATCAGATCCAGACCTTCGACATGAGC
CGTCTCCCTGATAACTGGGCGAGTGAGGATGCTCCTGCTGAGCTGGCGCTCTACGGTGATAACTGGGCTGAAAGCGGTTC
TTCTATCGCGCTGCGTATTCCAAGTGCGTTGTCTCCGGTTGAATTTAACTACTTGCTGAATCCGGCACACCCTGAACTCT
TTGACCTGATGGCTACGGTTAAGAAAATTCCGTTCCGGTTTGATTCCCGCCTGAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9486.84 Da        Isoelectric Point: 4.7246

>AT136735 WP_025343818.1 NZ_CP042966:613190-613438 [Sulfurospirillum multivorans]
MQAIFYSQARNNLRSIISKACTDFDQFIITTKDNQSVVLMSYDEYSAIKETMYLLSSKTNRDRLLDAVEEIEGMKFTCKE
IA

Download         Length: 249 bp

>AT136735 NZ_CP056201:c225253-224807 [Citrobacter sp. RHBSTW-00986]
ATGACGATGAAAGTTTTTTCTCCAGACGTTACCAAAACGAATCAGCACTGCTTATGGCAGGTTGCTGGGCTGGATAATGA
CGGTATCGCGCTGATGGATAAAATCAATCACGGTCTCGATGGCACAGTAGCTAAGCACATTTCTGAATGGGCTAACATCA
CGCCGTCTGAGCTGCGCAAAATGTCGGGTATACCTAATACGACGTTTAATCGTAGCATCAAAGACCGTTTCACTGCCGAT
CAGAGCGAACGTCTGGTGCGCATTATCCGCGTAATTGAACGCGCTGTAGAGCTGTTTGAAGGTGACAAAGAAGCGGCGCA
CAAATGGCTGAACGAAGCGAACCGTGGTCTGAGCTGGAAATCACCGGCAGAGCTTGTTTCTTCTGAGACAGGTGCGCTTG
AAGTGATGCGCCTGATTACGCGTATTGAGCACGGGGTATACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7THD5

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7THA9

References