Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3655447..3656101 Replicon chromosome
Accession NZ_CP042946
Organism Escherichia fergusonii strain ATCC 35470

Toxin (Protein)


Gene name cptA Uniprot ID F0JPE9
Locus tag ABH49_RS17680 Protein ID WP_000244774.1
Coordinates 3655694..3656101 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag ABH49_RS17675 Protein ID WP_000354046.1
Coordinates 3655447..3655713 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH49_RS17650 3650585..3651478 + 894 WP_105284375.1 transporter -
ABH49_RS17655 3651526..3652959 - 1434 WP_148047390.1 6-phospho-beta-glucosidase BglA -
ABH49_RS17660 3653004..3653315 + 312 WP_001182961.1 N(4)-acetylcytidine aminohydrolase -
ABH49_RS17665 3653479..3654138 + 660 WP_105284373.1 hemolysin III family protein -
ABH49_RS17670 3654215..3655195 - 981 WP_046080664.1 tRNA-modifying protein YgfZ -
ABH49_RS17675 3655447..3655713 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
ABH49_RS17680 3655694..3656101 + 408 WP_000244774.1 protein YgfX Toxin
ABH49_RS17685 3656141..3656662 - 522 WP_001055874.1 flavodoxin FldB -
ABH49_RS17690 3656774..3657670 + 897 WP_000806645.1 site-specific tyrosine recombinase XerD -
ABH49_RS17695 3657695..3658405 + 711 WP_046080663.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ABH49_RS17700 3658411..3660144 + 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16078.05 Da        Isoelectric Point: 11.2511

>T136728 WP_000244774.1 NZ_CP042946:3655694-3656101 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T136728 NZ_CP042946:3655694-3656101 [Escherichia fergusonii]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT136728 WP_000354046.1 NZ_CP042946:3655447-3655713 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT136728 NZ_CP042946:3655447-3655713 [Escherichia fergusonii]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGTGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6ZX35

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References