Detailed information of TA system TA136719

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1581354..1582026
• Replicon: chromosome
• Accession: NZ_CP042946
• Organism: Escherichia fergusonii strain ATCC 35470

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: ABH49_RS07590
• Protein ID: WP_046081139.1
• Coordinates: 1581706..1582026 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: ABH49_RS07585
• Protein ID: WP_046081138.1
• Coordinates: 1581354..1581674 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABH49_RS07555	1576443..1576721	-	279	WP_042004046.1	helix-turn-helix transcriptional regulator	-
ABH49_RS07560	1576987..1578399	-	1413	WP_046081135.1	DUF3987 domain-containing protein	-
ABH49_RS07565	1578714..1579385	-	672	WP_046081136.1	inovirus Gp2 family protein	-
ABH49_RS07570	1579783..1580601	+	819	WP_042004043.1	DUF945 domain-containing protein	-
ABH49_RS07575	1580634..1581107	+	474	WP_021555650.1	DNA repair protein RadC	-
ABH49_RS07580	1581115..1581336	+	222	WP_046081137.1	DUF987 family protein	-
ABH49_RS07585	1581354..1581674	+	321	WP_046081138.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
ABH49_RS07590	1581706..1582026	+	321	WP_046081139.1	TA system toxin CbtA family protein	Toxin
ABH49_RS07595	1582322..1583161	+	840	WP_046081140.1	nucleotide-binding protein	-
ABH49_RS07600	1584080..1584322	+	243	WP_000497434.1	DinI family protein	-
ABH49_RS07605	1584395..1584727	-	333	WP_105283992.1	heavy metal-binding domain-containing protein	-
ABH49_RS07610	1585008..1585970	-	963	WP_000361628.1	sugar-binding transcriptional regulator	-
ABH49_RS07615	1586094..1586951	-	858	WP_105283993.1	oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1569857..1584727	14870

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-105)

Antitoxin

• Antitoxin CbeA (4-102)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12017.70 Da
• Isoelectric Point: 5.9558

>T136719 WP_046081139.1 NZ_CP042946:1581706-1582026 [Escherichia fergusonii]
MHILSVPTTVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIEAGITLADAVNFLVEKYELVRIDRKGF
SWQNQTPFLSATDILRARRATGIMST

Nucleotide

• Length: 321 bp

>T136719 NZ_CP042946:1581706-1582026 [Escherichia fergusonii]
ATGCACATTTTATCTGTACCGACCACGGTGCCAGTTTCGTCACGTCTGTCTCCCGTGCAGGTCTGGCAGCAACTGCTAAC
GTATCTGCTGGAGCACCATTACGGACTGACGCTTAACGACACGCCATTCCACGACGACGCTGCTATCGAAGAACATATCG
AGGCGGGAATAACACTTGCTGATGCGGTGAATTTCCTGGTCGAAAAATACGAACTGGTTCGTATCGACCGGAAGGGATTT
TCATGGCAGAATCAAACGCCATTCCTCAGCGCTACCGATATTCTCAGAGCAAGGCGAGCTACGGGGATAATGAGCACTTA
A

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11996.70 Da
• Isoelectric Point: 6.5930

>AT136719 WP_046081138.1 NZ_CP042946:1581354-1581674 [Escherichia fergusonii]
MKNSWGLKRDMTPCFGARLVQEGCRLHFLADRADISGAFNEEEALRLDQAFPLVMKQLELMLTTGELHPRHQHCVTLHHN
GLTCEADTLGSHGYVYIVIYPQTSSQ

Nucleotide

• Length: 321 bp

>AT136719 NZ_CP042946:1581354-1581674 [Escherichia fergusonii]
ATGAAAAATTCATGGGGATTGAAGCGCGACATGACGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGATATTAGCGGTGCGTTTAATGAGGAGGAGGCGCTACGTCTGGATCAAGCATTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTACATCCACGCCATCAGCATTGCGTCACGTTGCATCATAAC
GGACTCACCTGCGAGGCGGATACTCTCGGCTCTCATGGCTACGTTTACATCGTTATTTATCCTCAGACATCGAGCCAGTA
A